A decade of the anaphase-promoting complex in the nervous system.
A decade of the anaphase-promoting complex in the nervous system.
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DOI：
10.1101/gad.274324.115
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发表时间：
2016-03-15
影响因子：
10.5
通讯作者：
Bonni A
中科院分区：
文献类型：
--
作者：
Huang J;Bonni A
在这篇综述中，Huang 和 Bonni 讨论了后期促进复合物在神经发生中的功能和机制；神经胶质分化和迁移；神经元存活、新陈代谢和形态发生；突触形成和可塑性；以及学习和记忆。泛素-蛋白酶体系统对蛋白质丰度的控制对于正常的大脑发育和功能至关重要。就在十多年前，人们发现了促进后期复合物（一种主要的细胞周期调节的 E3 泛素连接酶）的第一个有丝分裂后功能，它可以控制哺乳动物大脑中的轴突生长和模式。从那时起，大量研究已经确定了后期促进复合物在发育和成熟神经系统的神经元连接和可塑性的各个方面的其他新作用。在这篇综述中，我们讨论了后期促进复合物在神经发生、胶质细胞分化和迁移、神经元存活和代谢、神经元形态发生、突触形成和可塑性以及学习和记忆中的功能和机制。我们还为神经生物学中后期促进复合物的未来研究提供了视角。
In this review, Huang and Bonni discuss the functions and mechanisms of the anaphase-promoting complex in neurogenesis; glial differentiation and migration; neuronal survival, metabolism, and morphogenesis; synapse formation and plasticity; and learning and memory. Control of protein abundance by the ubiquitin–proteasome system is essential for normal brain development and function. Just over a decade ago, the first post-mitotic function of the anaphase-promoting complex, a major cell cycle-regulated E3 ubiquitin ligase, was discovered in the control of axon growth and patterning in the mammalian brain. Since then, a large number of studies have identified additional novel roles for the anaphase-promoting complex in diverse aspects of neuronal connectivity and plasticity in the developing and mature nervous system. In this review, we discuss the functions and mechanisms of the anaphase-promoting complex in neurogenesis, glial differentiation and migration, neuronal survival and metabolism, neuronal morphogenesis, synapse formation and plasticity, and learning and memory. We also provide a perspective on future investigations of the anaphase-promoting complex in neurobiology.