Self-assessment of Cognition in Multiple Sclerosis: The Role of Personality and Anxiety
Self-assessment of Cognition in Multiple Sclerosis: The Role of Personality and Anxiety
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DOI：
10.1097/wnn.0b013e31822a20ae
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发表时间：
2011-09-01
影响因子：
1.4
通讯作者：
Feinstein, Anthony
中科院分区：
文献类型：
--
作者：
Akbar, Nadine;Honarmand, Kimia;Feinstein, Anthony
目的：探讨人格和焦虑对多发性硬化症（MS）患者自我报告的认知测量的作用。背景：自我报告的认知测量一直被证明与MS患者的抑郁情绪比神经心理学测试表现更相关，很少有研究关注焦虑和人格的作用。（a）患者和被调查者报告多发性硬化症神经心理学问卷（MSNQ）;（B）医院焦虑和抑郁量表;（c）用简明可重复神经心理学测试组合进行认知评估;以及（d）使用自我报告NEO五因素量表进行人格评估。更高的患者MSNQ（P-MSNQ）评分（更大的认知功能障碍报告）与起搏听觉系列加法测试的较低分数显著相关（PASAT; r =-0.20，P < 0.05），抑郁（r = 0.45，P < 0.01）和焦虑（r = 0.54，P < 0.01）增加，神经质增高（r = 0.51，P < 0.01），焦虑降低（r =-0.35，P < 0.01）。在控制了人口统计学变量后，P-MSNQ评分的显著预测因素是焦虑（Delta R-2 = 0.272，P < 0.001）、焦虑（Delta R-2 = 0.067，P = 0.002）和PASAT成绩（Delta R-2 = 0.050，P = 0.005）。抑郁症和神经质没有贡献显着的方差相比，焦虑。结论：总体而言，病人的自我报告的认知没有对应的神经心理学表现。焦虑和焦虑对患者认知功能障碍的感知有显著影响，因此在处理这些投诉时应予以考虑。
Objective: To investigate the role of personality and anxiety to self-report measures of cognition in patients with multiple sclerosis (MS).Background: Self-report measures of cognition have consistently been shown to correlate better with depressed mood than neuropsychological test performance in patients with MS, with few studies focusing on the role of anxiety and personality.Method: One hundred eight MS patients completed the following: (a) patient and informant report Multiple Sclerosis Neuropsychological Questionnaire (MSNQ); (b) Hospital Anxiety and Depression Scale; (c) cognitive assessment with the Brief Repeatable Battery of Neuropsychological Tests; and (d) personality assessment using the self-report NEO Five-Factor Inventory.Results: Higher patient MSNQ (P-MSNQ) scores (greater reported cognitive dysfunction) were significantly correlated with lower scores on the Paced Auditory Serial Addition Test (PASAT; r = -0.20, P < 0.05), increased depression (r = 0.45, P < 0.01) and anxiety (r = 0.54, P < 0.01), higher neuroticism (r = 0.51, P < 0.01), and lower conscientiousness (r = -0.35, P < 0.01). After controlling for demographic variables, significant predictors of P-MSNQ scores were anxiety (Delta R-2 = 0.272, P < 0.001), conscientiousness (Delta R-2 = 0.067, P = 0.002), and performance on the PASAT (Delta R-2 = 0.050, P = 0.005). Depression and neuroticism did not contribute significant variance in comparison to anxiety.Conclusions: Overall, patient self-reports of cognition did not correspond well to neuropsychological performance. Anxiety and conscientiousness contributed significantly to patients' perceptions of their cognitive failings and thus should be taken into account when addressing these complaints.