Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
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DOI：
10.2337/diabetes.53.7.1643
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发表时间：
2004-07-01
期刊：
影响因子：
7.7
通讯作者：
Pedersen, BK
中科院分区：
文献类型：
--
作者：
Febbraio, MA;Hiscock, N;Pedersen, BK
肌肉工作过程中葡萄糖的产生和清除受到严格控制的机制尚不清楚，有人认为存在一个未知的“功因素”，它影响收缩诱导的内源性葡萄糖产生(EGP)的增加。细胞因子IL-6在收缩过程中从骨骼肌释放出来。在这里，我们表明，IL-6有助于收缩诱导的EGP增加。6名男子进行了3次不同的自行车运动，分别是相对高强度(HI)或低强度(LO+IL-6)或不注射(LO)与HI运动中IL-6循环浓度相匹配的重组人IL-6。输入稳定同位素6，6H-2(2)葡萄糖，计算EGP(葡萄糖出现率[R-a])、全身葡萄糖处置(葡萄糖消失率[R-d])和葡萄糖代谢清除率(MCR)。血糖R-a、R-d和MCR在HI时显著高于LO时(P<0.05)。在LO+IL-6的整个运动过程中，尽管运动强度相同，但血糖R-a和R-d均高于LO(P<；0.05)。此外，在90min时，LO+IL-6组的MCR高于LO组(P<0.05)。当比较LO+IL-6和LO时，胰岛素、胰升糖素、肾上腺素、去甲肾上腺素、皮质醇和生长激素是相同的。这些数据表明，IL-6影响运动过程中的血糖稳态。我们的结果为调节葡萄糖产生和处置的因素提供了潜在的新见解，并将IL-6牵涉到所谓的“功因素”中。
The mechanisms that mediate the tightly controlled production and clearance of glucose during muscular work are unclear, and it has been suggested that an unidentified "work factor" exists that influences the contraction-induced increase in endogenous glucose production (EGP). The cytokine interleukin (IL)-6 is released from skeletal muscle during contraction. Here we show that IL-6 contributes to the contraction-induced increase in EGP. Six men performed 2 It of bicycle exercise on three separate occasions, at a relatively high intensity (HI) or at a low intensity with (LO + IL-6) or without (LO) an infusion of recombinant human IL-6 that matched the circulating concentration of IL-6 seen in HI exercise. The stable isotope 6,6 H-2(2) glucose was infused to calculate EGP (rate of glucose appearance [R-a]), whole-body glucose disposal (rate of glucose disappearance [R-d]), and metabolic clearance rate (MCR) of glucose. Glucose R-a, R-d, and MCR were higher (P < 0.05) at HI than at LO. Throughout exercise at LO + IL-6, glucose R-a and R-d, were higher (P < 0.05) than LO, even though the exercise intensity was identical. In addition, MCR was higher (P < 0.05) at LO + IL-6 than at LO at 90 min. Insulin, glucagon, epinephrine, norepinephrine, cortisol, and growth hormone were identical when comparing LO + IL-6 with LO. These data suggest that IL-6 influences glucose homeostasis during exercise. Our results provide potential new insights into factors that mediate glucose production and disposal and implicates IL-6 in the so-called "work factor."