Autoantigenic histone epitopes: a comparison between procainamide- and hydralazine-induced lupus.

Autoantigenic histone epitopes: a comparison between procainamide- and hydralazine-induced lupus.
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自身抗原组蛋白表位:普鲁卡因酰胺和肼屈嗪诱导的狼疮之间的比较。

DOI:
10.1002/art.1780300612
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发表时间:
1987
影响因子:
--
通讯作者:
Hardin,JA
Hardin,JA
中科院分区:
--
文献类型:
--
作者:
Craft,JE;Radding,JA;Harding,MW;Bernstein,RM;Hardin,JA

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Using the technique of immunoblotting, we assessed the ability of sera from 19 patients with drug‐induced lupus to bind individual histones and specific histone fragments. The pattern of histone epitopes bound by sera from 9 patients with procainamide‐induced lupus was very similar to that described previously in spontaneous systemic lupus erythematosus. In contrast, sera from 10 patients with hydralazine‐induced lupus bound a broader array of individual histones and recognized a different set of histone epitopes. We conclude that these 2 drugs induce antihistone antibodies through somewhat different mechanisms, which possibly involve differences in their ability to structurally alter chromatin.
特发性狼疮和药物诱导狼疮中的抗组蛋白抗体可识别不同的组蛋白内区域。
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影响因子: 3.5
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DOI: --
发表时间: 1985
影响因子: --
作者:
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DOI: --
发表时间: 1982
期刊: EMBO Journal
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