COMPUTER-PROGRAMS FOR THE ANALYSIS OF CELLULAR-SURVIVAL DATA
COMPUTER-PROGRAMS FOR THE ANALYSIS OF CELLULAR-SURVIVAL DATA
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DOI：
10.2307/3577260
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发表时间：
1987-11-01
影响因子：
3.4
通讯作者：
ALBRIGHT, N
中科院分区：
文献类型：
--
作者：
ALBRIGHT, N
已经编写了四个程序，使放射生物学家能够建立细胞剂量-存活数据的计算机数据库，计算辐照时细胞多重性校正后的细胞存活，通过迭代加权最小二乘法将各种存活模型拟合到数据中，并计算与规定剂量对应的存活水平比率或产生规定存活水平的剂量比率（例如，氧增强比或相对生物有效性）。程序绘制生存曲线和数据图，并计算拟合的生存曲线参数和比率的标准误差和置信区间。该程序计算细胞存活的线性二次型、修复饱和型、单命中多目标型、线性多目标型和修复错配型模型的存活曲线，并已被设计用于适应未来其他存活模型的添加。这些程序可用于比较不同模型拟合数据的准确性，确定拟合差异是否具有统计显著性，并显示生存曲线参数的估计值（如外推数或最终斜率）如何随生存模型而变化。利用这些程序对辐射损伤的修复进行了新颖的分析。
Four programs have been written to enable radiobiologists to build a computer data base of cellular dose-survival data, calculate cell survival with a correction for cell multiplicity at the time of irradiation, fit various survival models to the data by iteratively weighted least squares, and calculate the ratio of survival levels corresponding to specified doses or the ratio of doses that produce specified survival levels (e.g., oxygen enhancement ratio or relative biological effectiveness). The programs make plots of survival curves and data, and they calculate standard errors and confidence intervals of the fitted survival curve parameters and ratios. The programs calculate survival curves for the linear-quadratic, repair-saturation, single-hit multitarget, linear-multitarget, and repair-mispair models of cell survival and have been designed to accommodate the addition of other survival models in the future. The programs can be used to compare the accuracy with which different models fit the data, determine if a differences in fit is statistically significant, and show how the estimated value of a survival curve parameter, such as the extrapolation number or the final slope, varies with the survival model. The repair of radiation-induced damage is analyzed in a novel way using these programs.