A longitudinal study of bone density in midlife women.
A longitudinal study of bone density in midlife women.
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DOI：
10.1080/07399330290107421
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发表时间：
2002-09-01
影响因子：
1.4
通讯作者：
Walker, Jane
中科院分区：
文献类型：
--
作者：
Holm, Karyn;Dan, Alice;Walker, Jane
对386名年龄在35-60岁之间的健康黑人和白色女性进行了一项纵向研究，以确定24个月内体力活动和其他相关因素对腰椎骨密度的影响。使用双能X射线（Hologic 1000）测量腰椎L2-L4的骨密度。通过问卷调查，从终身和当前的角度获得了三个维度（休闲，家庭和职业）的身体活动水平。体重指数的计算方法是测量的体重（千克）除以测量的身高（米）的平方。钙、咖啡因和酒精的摄入量通过食物频率问卷进行评估。年龄、种族和吸烟情况通过自我报告确定。卵泡刺激素（FSH）和雌二醇的放射免疫测定用于验证绝经状态的自我报告。多元回归分析显示，种族、年龄、体重、FSH、钙和烟草摄入年数在基线（r（2）= 0.32）和24个月（r（2）= 0.303）时形成了最佳模型。体力活动在两个时间点都不是骨密度的显著预测因子。骨密度随种族、年龄和绝经状态而发生横断面变化。黑人女性的骨密度明显高于白色女性。然而，在黑人和白色女性中，骨密度均呈现出与年龄相关的下降。围绝经期妇女的骨密度明显低于绝经前妇女。此外，37名（9.6%）妇女在基线和34名（11%）在24个月被指定为骨折的风险。
A longitudinal study of 386 healthy Black and White women aged 35-60 years was conducted to determine the effects of physical activity and other related factors on lumbar bone mineral density over 24 months. Bone mineral density of the lumbar spine, L2-L4, was measured using dual energy x-ray (Hologic 1000). Physical activity levels in three dimensions (leisure, household, and occupational) from both a lifelong and current perspective were obtained by questionnaire. Body mass index was calculated from measured weight in kilograms divided by measured height in meters squared. Calcium, caffeine, and alcohol intake was estimated using a food frequency questionnaire. Age, race, and smoking were determined by self-report. Radioimmunoassays of follicle stimulating hormone (FSH) and estradiol were used to validate self-reports of menopausal status. Multiple regression analysis revealed that race, age, weight, FSH, calcium, and years of tobacco intake formed the best model at baseline (r(2) = 0.32) and at 24 months (r(2) = 0.303). Physical activity was not a significant predictor for bone mineral density at either time point. There were cross-sectional changes of bone mineral density with race, age, and menopausal status. Black women had significantly higher bone mineral density than White women. However, an age-related decline in bone mineral density was exhibited in both Black and White women. Perimenopausal women had significantly lower bone mineral density as compared with premenopausal women. Furthermore 37 (9.6%) women at baseline and 34 (11%) at 24 months were designated at risk for fracture.