MENSTRUAL CYCLE-ASSOCIATED ALTERATION OF SULFOGALACTOSYLCERAMIDE IN HUMAN UTERINE ENDOMETRIUM - POSSIBLE INDUCTION OF GLYCOLIPID SULFATION BY SEX STEROID-HORMONES
MENSTRUAL CYCLE-ASSOCIATED ALTERATION OF SULFOGALACTOSYLCERAMIDE IN HUMAN UTERINE ENDOMETRIUM - POSSIBLE INDUCTION OF GLYCOLIPID SULFATION BY SEX STEROID-HORMONES
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DOI：
10.1016/0003-9861(89)90573-0
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发表时间：
1989-01-01
影响因子：
3.9
通讯作者：
NAGAI, Y
中科院分区：
文献类型：
--
作者：
KUBUSHIRO, K;KOJIMA, K;NAGAI, Y
人子宫内膜是一种细胞增殖和分化受性类固醇激素严格控制的组织，这些与子宫内膜月经周期相关的受性类固醇激素控制的细胞事件应伴有特征性分子和代谢变化。为了在分子水平上表征月经周期，我们分析了人子宫内膜在月经周期的增殖期和分泌期的糖脂。子宫内膜中性鞘糖脂主要由GlcCer、LacCer、Gb 3Cer和Gb 4Cer等球型鞘糖脂组成，且在两个时相的相对浓度保持恒定。然而，在酸性鞘糖脂的情况下，虽然唾液酸鞘糖脂的浓度在两个阶段中保持在恒定水平，但硫苷脂，I3-SulfoGalCer，从增殖期到分泌期显著增加，在增殖期达到7-17 nmol/g干重，在分泌期达到115-245 nmol/g干重。由于硫苷脂是唯一的糖脂，改变与月经周期，这是可能的磺基转移酶负责合成的硫苷脂可能是由性类固醇激素，雌激素和孕激素诱导，和硫苷脂可能发挥重要的生物学作用，在子宫内膜的月经周期的分泌期。
The human uterine endometrium is a tissue in which cell proliferation and differentiation are strictly controlled by sex steroid hormones, and these hormone-controlled cellular events occurring in association with the menstrual cycle of the uterine endometrium should be accompanied by characteristic molecular and metabolic changes. To characterize the menstrual cycle at the molecular level, we analyzed the glycolipids of human uterine endometrium in the proliferative and secretory phases of the menstrual cycle. Neutral glycosphingolipids from uterine endometrium comprised globo-series glycosphingolipids, such as GlcCer, LacCer, Gb3Cer, and Gb4Cer, and the relative concentrations remained constant in the two phases. However, in the case of acidic glycosphingolipids, although the concentrations of sialoglycosphingolipids remained at constant levels in the two phases, sulfatide, I3-SulfoGalCer, dramatically increased from the proliferative to the secretory phase, amounting to 7-17 nmol/g dry weight in the proliferative phase and 115-245 nmol/g dry weight in the secretory phase. Since sulfatide was the only glycolipid that changed in association with the menstrual cycle, it is likely that the sulfotransferase responsible for the synthesis of sulfatide might be induced by sex steroid hormones, estrogen and progesterone, and that sulfatide might play an essential biological role in the secretory phase of the menstrual cycle in the uterine endometrium.