Musculoskeletal health of subjects with hemophilia A treated with tailored prophylaxis: Canadian Hemophilia Primary Prophylaxis (CHPS) Study
Musculoskeletal health of subjects with hemophilia A treated with tailored prophylaxis: Canadian Hemophilia Primary Prophylaxis (CHPS) Study
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DOI：
10.1111/jth.12113
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发表时间：
2013-03-01
影响因子：
10.4
通讯作者：
Feldman, B.
中科院分区：
文献类型：
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作者：
Hilliard, P.;Zourikian, N.;Feldman, B.
全剂量预防在最大限度地减少关节损伤方面非常有效，但费用昂贵。定制预防已被提出作为一种降低成本的方式，同时仍然保护关节。目的报告56例参加加拿大血友病预防研究的重度血友病A患者13年后的索引关节的详细结果。方法对2002年1月至2004年12月间的重型血友病A患儿（
Background Full-dose prophylaxis is very effective at minimizing joint damage but is costly. Tailored prophylaxis has been proposed as a way of reducing costs while still protecting joints. Objective To report detailed findings in index joints of 56 subjects with severe hemophilia A entered into the Canadian Hemophilia Prophylaxis Study, and treated with tailored prophylaxis, after 13years. Methods Boys with severe hemophilia A (