Duration of ruptured membranes and mother-to-child HIV transmission: a prospective population-based surveillance study
Duration of ruptured membranes and mother-to-child HIV transmission: a prospective population-based surveillance study
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DOI：
10.1111/1471-0528.13442
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发表时间：
2016-05-01
影响因子：
5.8
通讯作者：
Townsend, C. L.
中科院分区：
文献类型：
--
作者：
Peters, H.;Byrne, L.;Townsend, C. L.
目的：在联合抗逆转录病毒疗法（cART）时代，研究胎膜破裂（ROM）持续时间与母婴人类免疫缺陷病毒（HIV）传播（MTCT）率之间的关联。
设计：英国孕期与儿童HIV研究（NSHPC）对孕妇和儿童中的HIV进行基于人群的综合监测。
地点：英国和爱尔兰。
人群：2007年至2012年期间，一组2398例单胎妊娠且孕期接受cART治疗的女性，她们经阴道分娩或急诊剖宫产，有胎膜破裂持续时间的信息；1898例婴儿有HIV感染状况的信息。
方法：对NSHPC数据进行描述性分析。
主要结局指标：MTCT率。
结果：在2116例足月分娩的妊娠中，胎膜破裂的中位持续时间为3小时30分钟（四分位间距，IQR为1 - 8小时）。胎膜破裂持续时间≥4小时的足月分娩女性的总体MTCT率为0.64%，而胎膜破裂持续时间＜4小时的总体MTCT率为0.34%。
ObjectiveTo investigate the association between duration of rupture of membranes (ROM) and mother-to-child HIV transmission (MTCT) rates in the era of combination antiretroviral therapy (cART).DesignThe National Study of HIV in Pregnancy and Childhood (NSHPC) undertakes comprehensive population-based surveillance of HIV in pregnant women and children.SettingUK and Ireland.PopulationA cohort of 2398 singleton pregnancies delivered vaginally, or by emergency caesarean section, in women on cART in pregnancy during the period 2007-2012 with information on duration of ROM; HIV infection status was available for 1898 infants.MethodsDescriptive analysis of NSHPC data.Main outcome measuresRates of MTCT.ResultsIn 2116 pregnancies delivered at term, the median duration of ROM was 3hours 30minutes (interquartile range, IQR 1-8hours). The overall MTCT rate for women delivering at term with duration of ROM 4hours was 0.64% compared with 0.34% for ROM