Ranitidine and oxygen derived free radical scavengers in haemorrhagic shock induced gastric lesions.
Ranitidine and oxygen derived free radical scavengers in haemorrhagic shock induced gastric lesions.
复制标题
雷尼替丁和氧衍生自由基清除剂在失血性休克引起的胃损伤中的作用。
DOI：
10.1136/gut.29.6.826
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发表时间：
1988
期刊：
影响因子：
24.5
通讯作者：
O. B. Kotoulas
中科院分区：
文献类型：
--
作者：
E C Tsimoyiannis;C. Sarros;J. Tsimoyiannis;K. Moutesidou;G. Akalestos;O. B. Kotoulas
研究了氧自由基在失血性休克引起的胃损伤中的作用以及氧自由基清除剂别嘌呤醇和雷尼替丁的保护作用。 45只兔子失血性休克30分钟，并回输流血。 30分钟后他们被杀。将动物分为五组：A (n = 10)：对照组，B (n = 10)：静脉注射雷尼替丁预处理，C (n = 10)：口服别嘌呤醇，术前 24 小时和 2 小时； D (n = 10)：用超氧化物歧化酶加过氧化氢酶进行静脉预处理，E (n = 5)：60 分钟失血性休克，无需再输注和治疗。观察到A组所有动物的糜烂和/或瘀点。 B 组和 C 组中的 3 只动物以及 D 组中的 2 只动物（p 小于 0.005，p 小于 0.001）有胃损伤。预处理组的病变明显小于对照组。氧自由基加上HCl在休克引起的胃损伤中起重要作用。氧自由基拮抗剂显示出显着的保护作用。
The role of oxygen derived free radicals in gastric lesions induced by haemorrhagic shock and the protective effect of oxygen radical scavengers, allopurinol and ranitidine, were investigated. Forty five rabbits underwent haemorrhagic shock for 30 minutes and reinfusion of shed blood. They were killed 30 minutes later. The animals were divided in five groups: A (n = 10): Control, B (n = 10): intravenous ranitidine pretreatment, C (n = 10): oral allopurinol, 24 and 2 h before surgery; D (n = 10): intravenous pretreatment with superoxide Dismutase plus catalase, E (n = 5): 60 minute haemorrhagic shock without reinfusion and treatment. Erosions and/or petechiae in all animals in Group A were observed. Three animals in group B and C and 2 in group D (p less than 0.005, p less than 0.001) had gastric lesions. The lesions in the pretreatment groups were significantly smaller than in controls. Oxygen radicals plus HCl play an important role in shock induced gastric lesions. Oxygen radical antagonists show a significant protective role.