SJOGRENS SYNDROME IN MRL/1 AND MRL/N MICE
SJOGRENS SYNDROME IN MRL/1 AND MRL/N MICE
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DOI：
10.1002/art.1780270206
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发表时间：
1984-01-01
影响因子：
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通讯作者：
WALKER, SE
中科院分区：
文献类型：
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作者：
HOFFMAN, RW;ALSPAUGH, MA;WALKER, SE
将六种自身免疫性小鼠模型（MRL/l、MRL/n、NZB、NZB/NZW、PN、C57 BL/6 J-lpr/lpr）与正常对照C57 BL/6 J和DBA/2小鼠进行比较，以确定自发性自身免疫性疾病是否与干燥综合征的证据相关。Schirmer试验记录了NZB/NZW和PN小鼠的干眼;其他自身免疫菌株和对照组具有正常的泪液形成。所有自身免疫小鼠都有结膜炎，但这种异常在PN株中最为严重。在MRL/l和MRL/n小鼠中，98%的泪腺中有单核细胞浸润，唾液腺受累程度较轻。新西兰小鼠和PN小鼠的腺体病变较小。MRL/l和MRL/n小鼠中广泛的腺体破坏表明这些亚系值得作为干燥综合征的动物模型进行进一步研究。
Six autoimmune murine models (MRL/l, MRL/n, NZB, NZB/NZW, PN, C57BL/6J-lpr/lpr) were compared with normal control C57BL/6J and DBA/2 mice to determine if spontaneous autoimmune disease was associated with evidence of Sjogren''s syndrome. Schirmer tests documented dry eyes in NZB/NZW and PN mice; other autoimmune strains and controls had normal tear formation. All autoimmune mice had conjunctivitis, but this abnormality was most severe in the PN strain. Of MRL/l and MRL/n mice, 98% had mononuclear cell infiltrates in lacrimal glands, and salivary glands were involved to a lesser degree. New Zealand mice and PN mice had smaller gland lesions. The extensive gland destruction in MRL/l and MRL/n mice suggested that these substrains merit further studies as animal models of Sjogren''s syndrome.