A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
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DOI：
10.1126/science.1141634
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发表时间：
2007-05-11
期刊：
影响因子：
56.9
通讯作者：
McCarthy, Mark I.
中科院分区：
文献类型：
--
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
肥胖是一个严重的国际健康问题，会增加几种常见疾病的风险。易感肥胖症的遗传因素知之甚少。对2型糖尿病敏感性的全基因组搜索基因鉴定了FTO（与脂肪质量和肥胖相关的）基因中的一种常见变体，该变异通过对体重指数（BMI）的影响而容易糖尿病。该变体与BMI的添加剂关联在13个队列中与38,759名参与者一起复制。与未继承风险等位基因的人相比，纯合的成年人中有16％的重量增加了约3公斤，肥胖的几率增加了1.67倍。从7岁开始观察到这种关联，并反映了脂肪质量的特异性增加。
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO ( fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.