Structural and functional diversity of collectins and ficolins and their relationship to disease.
Structural and functional diversity of collectins and ficolins and their relationship to disease.
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DOI：
10.1007/s00281-017-0642-0
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发表时间：
2018-01
影响因子：
9
通讯作者：
Sacks SH
中科院分区：
文献类型：
--
作者：
Howard M;Farrar CA;Sacks SH
模式识别分子是先天免疫系统的传感器，并在与微生物或改变的哺乳动物细胞上的相应配体相互作用后触发许多病理生理功能。在补体系统使用的那些模式识别分子中，胶原样凝集素（collectins）是重要的子组分。而最有名的这些凝集素，甘露糖结合凝集素，主要是作为一个循环的蛋白质肝细胞生产后，最近描述的凝集素表现出强烈的本地生物合成。这种可溶性聚集素分子的局部产生和释放似乎在血管外位点处服务于局部组织功能，包括发育功能。在这篇文章中，我们专注于聚集素-11（CL-11或CL-K1）的特性，其普遍表达和多种活性可能反映了广泛的生物学相关性。凝集素-11表现为急性期蛋白，其产生与代谢和物理应激相关，导致局部靶向炎症和组织细胞死亡。早期的结果表明岩藻糖基化配体标记胶原聚集蛋白-11靶向的损伤细胞的重要性，我们建议进一步表征这种配体和相关配体将导致更好地理解病理生理学意义和临床获益。
Pattern recognition molecules are sensors for the innate immune system and trigger a number of pathophysiological functions after interaction with the corresponding ligands on microorganisms or altered mammalian cells. Of those pattern recognition molecules used by the complement system, collagen-like lectins (collectins) are an important subcomponent. Whereas the best known of these collectins, mannose-binding lectin, largely occurs as a circulating protein following production by hepatocytes, the most recently described collectins exhibit strong local biosynthesis. This local production and release of soluble collectin molecules appear to serve local tissue functions at extravascular sites, including a developmental function. In this article, we focus on the characteristics of collectin-11 (CL-11 or CL-K1), whose ubiquitous expression and multiple activities likely reflect a wide biological relevance. Collectin-11 appears to behave as an acute phase protein whose production associated with metabolic and physical stress results in locally targeted inflammation and tissue cell death. Early results indicate the importance of fucosylated ligand marking the injured cells targeted by collectin-11, and we suggest that further characterisation of this and related ligands will lead to better understanding of pathophysiological significance and exploitation for clinical benefit.
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影响因子：
4.4
作者：
Banda, Nirmal K.;Takahashi, Kazue;Arend, William P.
通讯作者：
Arend, William P.
影响因子：
6.7
作者：
Ali YM;Lynch NJ;Haleem KS;Fujita T;Endo Y;Hansen S;Holmskov U;Takahashi K;Stahl GL;Dudler T;Girija UV;Wallis R;Kadioglu A;Stover CM;Andrew PW;Schwaeble WJ
通讯作者：
Schwaeble WJ
DOI：
10.4049/jimmunol.1400752
发表时间：
2014-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banda NK;Mehta G;Kjaer TR;Takahashi M;Schaack J;Morrison TE;Thiel S;Arend WP;Holers VM
通讯作者：
Holers VM
影响因子：
5.5
作者：
Cruyssen, B. Vander;Nuytinck, L.;De Keyser, F.
通讯作者：
De Keyser, F.
影响因子：
64.5
作者：
Gardai, SJ;Xiao, YQ;Henson, PM
通讯作者：
Henson, PM