Association of ADRB2 polymorphism with triglyceride levels in Tongans.
Association of ADRB2 polymorphism with triglyceride levels in Tongans.
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DOI：
10.1186/1476-511x-12-110
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发表时间：
2013-07-23
影响因子：
4.5
通讯作者：
Matsumura Y
中科院分区：
文献类型：
--
作者：
Naka I;Ohashi J;Kimura R;Inaoka T;Matsumura Y
我们的前期研究表明，β2肾上腺素能受体基因（ADRB 2）上游区域rs34623097单核苷酸多态性（SNP）A等位基因与大洋洲人群肥胖风险显著相关。为了研究ADRB 2多态性是否解释了脂质动员、能量消耗和糖原分解的部分个体差异，在汤加的128名成年人中检查了10个ADRB 2 SNP与总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯水平的相关性。经年龄、性别和体重指数校正的多元线性回归分析显示，rs34623097与甘油三酯水平显著相关（P值= 0.037）。rs34623097-A等位基因的拷贝使血清甘油三酯水平增加70.1 mg/dL（0.791 mmol/L）。ADRB 2单核苷酸多态性与总胆固醇、高密度脂蛋白胆固醇或低密度脂蛋白胆固醇均无显著相关性。在汤加人群中，位于ADRB 2上游区域的SNP与甘油三酯水平相关，而与体重指数无关。
Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations. To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga. A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels (P-value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the ADRB2 SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol. In a Tongan population, a SNP located in the upstream region of ADRB2 is associated with triglyceride levels independent of body mass index.