Characterization of hind paw licking and lifting to noxious radiant heat in the rat with and without chronic inflammation
Characterization of hind paw licking and lifting to noxious radiant heat in the rat with and without chronic inflammation
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DOI：
10.1016/j.jneumeth.2006.01.001
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发表时间：
2006-07-15
影响因子：
3
通讯作者：
Cheppudira, Bopaiah Pooviah
中科院分区：
文献类型：
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作者：
Cheppudira, Bopaiah Pooviah
热辐射热刺激的缩爪潜伏期是研究痛觉过敏机制的常用伤害性指标。在本研究中，除了缩爪潜伏期外，还对疼痛行为的两个行为组成部分舔爪和提爪进行了表征和量化。将热刺激连续施加到大鼠后爪的足底表面，并记录对每种刺激的行为反应。辐射热能显著增加未处理大鼠的举爪行为频率。另一方面，热刺激显著诱发发炎爪中舔爪行为的发生，并且在测量的所有时间点保持。与对照组大鼠相比，炎症大鼠的缩足潜伏期缩短。这些数据表明，有害辐射热特别引起正常生理条件下的举爪行为和病理炎症条件下的舔爪行为的频率。这些发现表明，除了PWL的测量，舔爪和举起行为的评分将提高这种疼痛测试的灵敏度。(c)2006 Elsevier B.V.保留所有权利。
The paw withdrawal latency to thermal radiant heat stimuli is a widely used nociceptive measure to study hyperalgesic mechanisms. In the present study, in addition to the paw withdrawal latency, two behavioral components of pain behaviors, paw licking and paw lifting have been characterized and quantified. The thermal stimuli were successively applied to the plantar surface of the rat hind paws and recorded the behavioral responses to each of the stimuli. Noxious radiant heat significantly increased the frequency of paw lifting behavior in naive rats. On the other hand, the thermal stimuli significantly evoked the occurrence of paw licking behavior in inflamed paws and it was maintained at all time points of measurements. The paw withdrawal latency decreased in inflamed rats in comparison with control rats. These data informs that noxious radiant heat specifically evokes the frequency of paw lifting behavior in normal physiological condition, and paw licking behavior in a pathological inflammatory condition. These findings suggest that in addition to the measurement of PWL, scoring of paw licking and lifting behaviors will improve the sensitivity of this pain test. (c) 2006 Elsevier B.V. All rights reserved.