Genetics of gonadal stem cell renewal.
Genetics of gonadal stem cell renewal.
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DOI：
10.1146/annurev-cellbio-100913-013344
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发表时间：
2015
影响因子：
11.3
通讯作者：
Matunis E
中科院分区：
文献类型：
--
作者：
Greenspan LJ;de Cuevas M;Matunis E
干细胞是维持许多成人组织所必需的。干细胞微环境或生态位内的信号调节这些细胞的自我更新和分化能力。通过突变或损伤对这些信号的错误调节可导致不同干细胞库的过度生长或耗尽。在这篇综述中，我们专注于果蝇睾丸和卵巢，这两者都包含明确的壁龛，以及小鼠睾丸，这已成为一个更平易近人的干细胞系统与最近的技术进步。我们讨论的信号，调节性腺干细胞在他们的小生境，这些信号如何介导自我更新和分化的稳态条件下，以及如何应力，无论是从突变或损伤，可以引起细胞命运的变化和驱动干细胞竞争。
Stem cells are necessary for the maintenance of many adult tissues. Signals within the stem cell microenvironment, or niche, regulate the self-renewal and differentiation capability of these cells. Misregulation of these signals through mutation or damage can lead to overgrowth or depletion of different stem cell pools. In this review, we focus on the Drosophila testis and ovary, both of which contain well-defined niches, as well as the mouse testis, which has become a more approachable stem cell system with recent technical advances. We discuss the signals that regulate gonadal stem cells in their niches, how these signals mediate self-renewal and differentiation under homeostatic conditions, and how stress, whether from mutations or damage, can cause changes in cell fate and drive stem cell competition.