Ruthenium-catalysed synthesis of tertiary amines from alcohols
Ruthenium-catalysed synthesis of tertiary amines from alcohols
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DOI：
10.1016/j.tetlet.2007.09.134
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发表时间：
2007-11-19
影响因子：
1.8
通讯作者：
Williams, Jonathan M. J.
中科院分区：
文献类型：
--
作者：
Haniti, M.;Hamid, S. A.;Williams, Jonathan M. J.
仲胺通过与伯醇反应转化为叔胺。[Ru（cymene）Cl-2]（2）与dppf的催化体系已被证明对一系列伯醇和仲胺的这种转化是有效的。该方法已被应用到一锅法合成吡贝地尔和其他哌嗪和吗啉含产品。(C)2007爱思唯尔有限公司版权所有。
Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.