THE UNIQUE POSTTRANSLATIONAL MODIFICATION LEADING TO DEOXYHYPUSINE OR HYPUSINE IS A GENERAL FEATURE OF THE ARCHAEBACTERIAL KINGDOM
THE UNIQUE POSTTRANSLATIONAL MODIFICATION LEADING TO DEOXYHYPUSINE OR HYPUSINE IS A GENERAL FEATURE OF THE ARCHAEBACTERIAL KINGDOM
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DOI：
10.1016/s0723-2020(11)80156-6
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发表时间：
1990-05-01
影响因子：
3.4
通讯作者：
KLINK, F
中科院分区：
文献类型：
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作者：
BARTIG, D;SCHUMANN, H;KLINK, F
对代表约四分之三已知门的各种古细菌物种的细胞蛋白的研究表明，合成蛋白质结合的脱氧马尿苷和/或马尿苷的能力显然是该界所有需氧和厌氧生物体的共同特征。脱氧马尿苷含量在 6 至 78 nmol/g 蛋白质之间变化，马尿苷含量在 2 至 41 nmol/g 蛋白质之间变化。缺乏或极低水平的山马尿苷对应于高浓度的脱氧山马尿碱，这表明脱氧山马尿苷可能在其未知功能上替代山马尿苷。 Thermoproteus tenax、Pyrodictium ocultum 和 Desulfurolobus ambivalens 在没有分子氧的情况下羟基化脱氧马尿苷的能力表明了与真核生物中发现的另一种羟基化机制。
Investigations of cell protein from various archaebacterial species representing about three fourths of the known phyla revealed that the ability to synthesize protein-bound deoxyhypusine and/or hypusine is apparently a common feature of all aerobic and anaerobic organisms of this kingdom. The deoxyhypusine contents varied between 6 and 78 nmol/g protein, the hypusine contents between 2 and 41 nmol/g protein. The lack or very low levels of hypusine corresponded to high concentrations of deoxyhypusine suggesting that deoxyhypusine may substitute for hypusine in its unknown function. The ability of Thermoproteus tenax, Pyrodictium occultum and Desulfurolobus ambivalens to hydroxylate deoxyhypusine in the absence of molecular oxygen points to another hydroxylation mechanism than that found in eukaryotes.