ADHESION OF REGENERATING CORNEAL EPITHELIUM - ROLE OF BASEMENT MEMBRANE
ADHESION OF REGENERATING CORNEAL EPITHELIUM - ROLE OF BASEMENT MEMBRANE
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DOI：
10.1016/0002-9394(68)93082-1
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发表时间：
1968-01-01
影响因子：
4.2
通讯作者：
DOWLING, JE
中科院分区：
文献类型：
--
作者：
KHODADOUST, AA;SILVERSTEIN, AM;DOWLING, JE
角膜浅表伤口的愈合至少涉及两个主要过程：缺损上完整上皮细胞层的更新，以及新上皮与底层组织之间紧密粘连的重建。当角膜被机械刮擦时，原来的基底膜可以完好无损地保存下来，并被新的上皮细胞重新利用。在这种情况下，与基底膜建立紧密的上皮黏附似乎需要几天时间。当上皮和基底膜都被切除时，如在浅表角膜切除术中，再生上皮形成新的基底膜，并与下层基质粘连，可能需要数周时间。本文讨论了基底膜缺损在角膜创面愈合过程中的意义及其在复发性角膜糜烂发病机制中的可能意义。
The healing of superficial corneal wounds involves at least 2 principal processes: the renewal of an intact layer of epithelial cells over the defect, and the reestablishment of a tight adhesion between the new epithelium and the underlying tissue. When the cornea is mechanically scraped, the original basement membrane may survive intact and be reutilized by the new epithelium. In this instance, establishment of tight epithelial adhesion to the basement membrane appears to require several days. When both epithelium and basement membrane are removed, as in superficial keratectomy, formation of a new basement membrane by the regenerating epithelium, and its adhesion to the underlying stroma, may require many weeks. The significance of basement membrane defects in the process of corneal wound healing, and its possible implications in the pathogenesis of recurrent corneal erosion are discussed.