Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI
Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI
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DOI：
10.1271/bbb.50698
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发表时间：
2006-10-01
影响因子：
1.6
通讯作者：
Yang, Ching-Huey
中科院分区：
文献类型：
--
作者：
Huang, Wen-Hsin;Lee, An-Rong;Yang, Ching-Huey
黄芩的活性成分为黄芩素、木脂素A和汉黄芩素等多羟基黄酮类化合物。为克服黄芩甙7-O-硫酸酯溶解性差的缺点，研究其构效关系，制备了黄芩甙7-O-硫酸酯，并进行了广泛的抗氧化和抗炎实验。所有的多羟基黄酮具有明显的抗氧化和清除自由基的活性。在抑制一氧化氮（NO）方面，汉黄芩素是上级的所有其他黄酮类化合物，而木脂素A是最有效的抑制脂质过氧化作用。汉黄芩素对角叉菜胶诱导的大鼠后爪水肿的抑制作用最强（82.9%抑制，p < 0.05）。在体内抗炎活性和体外抗氧化活性之间存在相关性。
The active ingredients of 'golden root' of Scutellaria baicalensis GEORGI (Huang-Qin), a valuable traditional Chinese medicine, are polyhydroxyflavonoids, namely baicalein, oroxylin A and wogonin. With the objective of overcoming their poor solubility and to investigate their structure and activity relationships, baicaleinyl 7-O-sulfate was prepared, and extensive comparative antioxidative and anti-inflammatory tests were conducted. All the polyhydroxyflavonoids exhibited significant antioxidative and free-radical scavenging activities. In respect of their nitric oxide (NO) inhibition, wogonin was superior to all the other flavonoids, while oroxylin A was most potent in the inhibition of lipid peroxidation. Wogonin proved to be the most potent (82.9% inhibition, p < 0.05) in its antiinflammatory activity against carrageenan-induced rat hind paw edema. There was a correlation between the in-vivo anti-inflammatory activity and the in-vitro antioxidative activities.