Expression of hsp90 and cyclin D1 in human breast cancer
Expression of hsp90 and cyclin D1 in human breast cancer
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DOI：
10.1016/s0304-3835(98)00338-3
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发表时间：
1999-03-22
期刊：
影响因子：
9.7
通讯作者：
Asano, G
中科院分区：
文献类型：
--
作者：
Yano, M;Naito, Z;Asano, G
热休克蛋白（hsps）在细胞周期和导致肿瘤发生的多步骤过程中的不可或缺的作用已经被暗示。我们检测了人类乳腺癌中 hsp90 α、hsp90 β 和细胞周期蛋白 D1 的表达。癌组织中编码 hsp90 α 和细胞周期蛋白 D1 的 mRNA 水平显着高于非癌组织。此外，两种 mRNA 水平之间存在密切关系，表明 hsp90 家族亚型 hsp90 α 表达的增加与人类乳腺癌的增殖相关。 Hsp90 beta 在癌细胞中表达，但与细胞增殖无关。 (C) 1999 Elsevier Science Ireland Ltd. 保留所有权利。
The integral roles of heat shock proteins (hsps) in the cell cycle and in multistep processes leading to tumorigenesis have been implied. We examined the expression of hsp90 alpha, hsp90 beta and cyclin D1 in human breast cancer. Levels of mRNAs coding for hsp90 alpha and cyclin D1 were significantly higher in cancer tissues than in non-cancer tissues. Moreover, there was a close relationship between the extent of the two mRNA levels, suggesting that increased expression of hsp90 alpha, an isoform of the hsp90 family, is associated with the proliferation of human breast cancer. Hsp90 beta was expressed in cancer cells, but not associated with cell proliferation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.