Degradation of relaxin family peptides by insulin-degrading enzyme.
Degradation of relaxin family peptides by insulin-degrading enzyme.
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DOI：
10.1111/j.1749-6632.2008.03782.x
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发表时间：
2009-04
影响因子：
5.2
通讯作者：
Hamel FG
中科院分区：
文献类型：
--
作者：
Bennett RG;Heimann DG;Hamel FG
Insulin-degrading enzyme (IDE) is a ubiquitously expressed metalloproteinase responsible for the intracellular degradation of insulin. IDE also interacts with other members of the insulin superfamily, including relaxin, but no studies have been reported regarding the interaction of other relaxin-like peptides with IDE. In this study, we determined that relaxin, relaxin-3 and InsL3 all competitively inhibited the degradation of insulin by IDE to different degrees, and all inhibited covalent cross-linking of insulin to IDE. Each of the peptides was degraded by IDE to various degrees (insulin>relaxin>InsL3=relaxin-3). In summary, relaxin, InsL3 and relaxin-3 all bound to IDE, competed with the binding and degradation of insulin, and were all substrates for the proteolytic activity of IDE. Therefore, it is possible that in addition to insulin, IDE may be important for the cellular proteolysis of relaxin, InsL3 and relaxin-3.
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影响因子：
3.5
作者：
KUROCHKIN, IV;GOTO, S
通讯作者：
GOTO, S
影响因子：
4.2
作者：
Lynch, John A.;George, Ana M.;Fine, Richard E.
通讯作者：
Fine, Richard E.
影响因子：
4.8
作者：
Bennett, RG;Duckworth, WC;Hamel, FG
通讯作者：
Hamel, FG
影响因子：
3.5
作者：
Fakhrai-Rad, H;Nikoshkov, A;Galli, J
通讯作者：
Galli, J
DOI：
10.1073/pnas.0230450100
发表时间：
2003-04-01
影响因子：
11.1
作者：
Farris, W;Mansourian, S;Guénette, S
通讯作者：
Guénette, S