Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma
Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma
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DOI：
10.1016/j.pedneo.2018.01.005
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发表时间：
2018-12-01
影响因子：
2.1
通讯作者：
Huang, Jing-Long
中科院分区：
文献类型：
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作者：
Huang, Shu-Jung;Lin, Li-Lun;Huang, Jing-Long
背景：气道高反应性（AHR）是哮喘的一个重要特征，可通过各种支气管激发试验检测。在儿科人群中，哮喘儿童乙酰甲胆碱激发试验（MCCT）阳性的百分比在不同研究中有所不同，有些研究报告了季节性变化。然而，这些研究大多是在温带地区进行的。本研究评估了在台湾，一个亚热带国家的哮喘儿童的乙酰甲胆碱AHR的患病率和季节性变化。方法：共276名儿童哮喘和他们的MCCT结果进行了回顾性分析。所有人都被诊断患有哮喘，并定期接受哮喘控制。他们被分配到四个季节组取决于哪个季节MCCT管理，与台湾中央气象局的季节分类。亚组分析，包括性别，年龄，和特异性反应水平，比较季节difference.Results：乙酰甲胆碱高反应性的患病率为70.7%（n = 195），和儿童谁是年轻的，有较高的血清总IgE更敏感乙酰甲胆碱（p = 0.019和p < 0.005，分别）。各季节AHR患病率无显著差异（p = 0.480）。临界，轻度和中度严重程度的MCCT结果的百分比几乎均匀分布在季节之间。在亚组分析中，IgE水平较高的儿童（所有数据的>= 75百分位数）在夏季有较高的MCCT阳性比例（88.6%，p = 0.016）。结论：总体而言，台湾70%的哮喘儿童对乙酰甲胆碱有AHR，这在季节之间变化。血清总IgE水平较高的儿童可能更依赖于季节性，特别是在夏季。版权所有（C）2018，台湾儿科医学会.出版社：Elsevier Taiwan LLC
Background: Airway hyperresponsiveness (AHR) is a key feature of asthma and can be detected using various bronchoprovocation tests. In pediatric populations, the percentage of a positive methacholine challenge test (MCCTs) in children with asthma varies among studies, and some have reported seasonal variability. However, these studies have mostly been conducted in temperate regions.This study evaluated the prevalence of AHR to methacholine and its seasonal variation in asthmatic children in Taiwan, a subtropical country.Methods: A total of 276 children with asthma and their MCCT results were retrospectively reviewed. All were diagnosed with asthma and received asthma controllers regularly. They were assigned to four season groups depending in which season MCCTs were administered, with seasons categorized by the Central Weather Bureau of Taiwan. Subgroup analyses, including for sex, age, and atopy level, were compared for seasonal difference.Results: The prevalence of methacholine hyperresponsiveness was 70.7% (n = 195), and the children who were younger and had higher total serum IgE were more sensitive to methacholine (p = 0.019 and p < 0.005, respectively). No significant difference in AHR prevalence among seasons was observed (p = 0.480). The percentage of borderline, mild, and moderate severity of MCCT results was almost equally distributed among the seasons. In subgroup analysis, the children with a higher IgE level (>= 75th percentile of all data) had a higher proportion of positive MCCTs in summer (88.6%, p = 0.016).Conclusion: In total, 70% of the children with asthma in Taiwan had AHR to methacholine, which varied among seasons. Children with a higher total serum IgE level may be more seasonally dependent, particularly in summer. Copyright (C) 2018, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.