Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain
Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain
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DOI：
10.1038/sj.bjp.0702472
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发表时间：
1999-04-01
影响因子：
7.3
通讯作者：
Brodie, MJ
中科院分区：
文献类型：
--
作者：
Fraser, CM;Sills, GJ;Brodie, MJ
1谷氨酰胺合成酶(GS)是调节中枢神经系统谷氨酸神经传递的关键酶。它负责谷氨酸转化为谷氨酰胺，并负责氨解毒。2我们研究了一系列已有的和新的抗癫痫药物单次和重复给药对小鼠脑内GS活性的影响。3最后一次给药4小时后，动物处死动物，取脑组织进行GS活性分析。4单次和重复剂量的苯妥英钠和卡马西平均可降低酶活性(P
1 Glutamine synthetase (GS) is a key enzyme in the regulation of glutamate neurotransmission in the central nervous system. It is responsible for the conversion of glutamate to glutamine, and for the detoxification of ammonia.2 We have investigated the effects of single and repeated intraperitoneal administration of a range of established and new anti-epileptic drugs on GS activity in mouse brain.3 Four hours after the final dose, animals were sacrificed and the brains removed for analysis of GS activity.4 Both single and repeated doses of phenytoin and carbamazepine were found to reduce enzyme activity (P