Cardiac basal and activation metabolism.
Cardiac basal and activation metabolism.
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心脏基础代谢和活化代谢。
DOI：
--
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发表时间：
1987
影响因子：
9.5
通讯作者：
D. Loiselle
中科院分区：
文献类型：
--
作者：
D. Loiselle
心脏基础代谢是静止心肌的能量消耗速率。它与物种有关，并随着预负荷的增加而增加。它对膜结合阳离子泵的贡献很小。蛋白质新陈代谢的作用仍有待商榷。计算表明，线粒体质子泵可能占心脏基础代谢的很大一部分。然而，从本质上讲，人们对这一组成部分仍不甚了解。心脏激活代谢是与激活收缩的过程相关的超基础能量消耗速率。在单独的肌肉准备中，它通常被测量为肌肉的产热或耗氧率，预先缩短到一个可以忽略主动力量产生的长度，尽管它也是通过药物干预来估计的。在全心脏研究中，它是以空的、跳动的但非工作的心脏的超基础耗氧率为指标的。激活代谢包括电兴奋(ECG)和兴奋-收缩耦合(钙离子循环)。它是由增加收缩能力的试剂增加的；它可能随着预负荷的增加而增加，这是通过依赖长度的激活现象来实现的。在正常情况下，基础成分和激活成分各占心脏总能量消耗的四分之一至三分之一。
Cardiac basal metabolism is the rate of energy expenditure of the quiescent myocardium. It is species dependent and increases with pre-load. It has small contributions from membrane-bound cation pumps. The contribution of protein metabolism remains open to question. Calculations show that mitochondrial proton pumping may account for a large fraction of the cardiac basal metabolism. Nevertheless this component remains essentially ill-understood. Cardiac activation metabolism is the supra-basal rate of energy expenditure associated with those processes that activate contraction. In isolated muscle preparations it is typically measured as the rate of heat production or oxygen consumption of a muscle, pre-shortened to a length where active force production is negligible, although it is also estimated by pharmacological intervention. In whole-heart studies it is indexed by the supra-basal rate of oxygen consumption of the empty, beating but non-working heart. Activation metabolism underwrites electrical excitation (the ECG) and excitation-contraction coupling (the cycling of calcium ions). It is increased by agents that increase contractility; it probably increases with pre-load, via the phenomenon of length-dependent activation. The basal and activation components each account for one-quarter to one-third of the total energy expenditure of the heart under normal conditions.
刺激频率对心脏组织中钾活性和细胞体积的影响。
DOI：
10.1152/ajpcell.1981.240.1.c39
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Browning,DJ;Strauss,HC
通讯作者：
Strauss,HC
骨骼肌收缩期间 Ca2 循环的能量。
DOI：
--
发表时间：
1982
期刊：
Federation proceedings
影响因子：
--
作者：
Rall,JA
通讯作者：
Rall,JA