Combining zooprophylaxis and insecticide spraying: a malaria-control strategy limiting the development of insecticide resistance in vector mosquitoes
Combining zooprophylaxis and insecticide spraying: a malaria-control strategy limiting the development of insecticide resistance in vector mosquitoes
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DOI：
10.1098/rspb.2003.2575
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发表时间：
2004-02-07
影响因子：
4.7
通讯作者：
Mogi, M
中科院分区：
文献类型：
--
作者：
Kawaguchi, I;Sasaki, A;Mogi, M
根除病媒传播的传染病（例如疟疾和日本脑炎）的战略往往着眼于用杀虫剂控制病媒。然而，喷洒杀虫剂为病媒产生抗药性开辟了道路，这可能导致疾病控制的失败。本文研究了杀虫剂喷雾和动物预防联合使用是否能限制蚊虫抗药性的发展。动物预防是指通过将病媒吸引到病原体无法扩增的家畜（终端宿主）来控制病媒传播的疾病。人类疟疾寄生虫疟原虫在人类和蚊子之间有一个封闭的传播周期，因此牛可以作为一个死角宿主。我们的模型表明，在某些情况下，通过选择适当的杀虫剂喷洒率和牛的密度和位置，可以在不产生杀虫剂抗性的情况下控制疟疾。
Strategies to eradicate the vector-borne infectious diseases (e.g. malaria and Japanese encephalitis) are often directed at controlling vectors with insecticides. Spraying insecticide, however, opens the way for the development of insecticide resistance in vectors, which may lead to the failure of disease control. In this paper, we examine whether the combined use of insecticide spray and zooprophylaxis can limit the development of insecticide resistance in mosquitoes. Zooprophylaxis refers to the control of vector-borne diseases by attracting vectors to domestic animals in which the pathogen cannot amplify (a dead-end host). The human malaria parasite Plasmodium spp. has a closed transmission cycle between humans and mosquitoes, and hence cattle can serve as a dead-end host. Our model reveals that, by a suitable choice of insecticide spraying rate and cattle density and location, malaria can, in some situations, be controlled without mosquitoes developing insecticide resistance.