Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV8), related to suppression of Anopheles density in Italy
Reduced seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV), human herpesvirus 8 (HHV8), related to suppression of Anopheles density in Italy
复制标题
DOI：
10.1111/j.1365-2915.2003.00465.x
复制
发表时间：
2003-12-01
影响因子：
1.9
通讯作者：
Ascoli, V
中科院分区：
文献类型：
--
作者：
Coluzzi, M;Calabrò, ML;Ascoli, V
在意大利的两个以前疟疾猖獗的地区，从当地献血者那里测定了卡波西肉瘤相关疱疹病毒[人类疱疹病毒8（KSHV/HHV 8）]与年龄相关的血清阳性率，并将其与抗疟疾活动期间的病媒控制时期相关联。在韦内托，1951-1955年出生队列中KSHV/HHV 8血清阳性率的下降与滴滴涕室内喷洒的高峰相吻合。在撒丁岛，杀幼虫剂增强室内DDT喷洒，KSHV/HHV 8血清阳性率显着下降1945年和1950年和1951-1955年出生队列（P = 0.0046）与疟疾媒介按蚊labranchiae Falleroni（双翅目：蚊科）的抑制相一致。这些结果是一致的与年龄相关的关联KSHV/HHV 8血清阳性率在本地/居民人口和疟疾媒介的密度在韦内托和撒丁岛。这个例子支持我们的'启动子节肢动物'的假设的作用吸血昆虫[pupuliusblackflies（蚋科），白蛉（白蛉亚科）和蠓（蠓科）以及蚊子]，当它们的叮咬引起过敏和免疫抑制时，增强KSHV/HHV 8通过人唾液的传播（当昆虫叮咬的伤口被另一个唾液携带病毒的人舔过时），并可能促进卡波西肉瘤。
In two formerly malarious parts of Italy, age-related seroprevalence rates of Kaposi's sarcoma-associated herpesvirus [human herpesvirus 8 (KSHV/HHV8)] were determined from local blood donors and correlated with periods of vector control during anti-malaria campaigns. In Veneto, decreased KSHV/HHV8 seroprevalence in the 1951-1955 birth cohort coincides with the peak of DDT house-spraying. In Sardinia, where larviciding augmented indoor DDT-spraying, a significant drop of KSHV/HHV8 seroprevalence between 1945 and 1950 and 1951-1955 birth cohorts (P = 0.0046) coincides with suppression of the malaria vector Anopheles labranchiae Falleroni (Diptera: Culicidae). These results are consistent with age-related association between KSHV/HHV8 seroprevalence rates in native/resident populations and the density of malaria vectors in Veneto and Sardinia. This example supports our 'promoter arthropod' hypothesis on the role of haematophagous insects [putatively blackflies (Simuliidae), sandflies (Phlebotominae) and biting midges (Ceratopogonidae), as well as mosquitoes] when their bites induce hypersensitivity and immunosuppression, potentiate KSHV/HHV8 transmission via human saliva (when insect bite lesions are licked by another person whose saliva carries the virus) and may facilitate Kaposi's sarcoma.