Universal disease biomarker: can a fixed set of blood microRNAs diagnose multiple diseases?
Universal disease biomarker: can a fixed set of blood microRNAs diagnose multiple diseases?
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DOI：
10.1186/1756-0500-7-581
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发表时间：
2014-08-30
影响因子：
1.8
通讯作者：
Murakami Y
中科院分区：
文献类型：
--
作者：
Taguchi YH;Murakami Y
疾病生物标志物的选择通常是困难的，因为它们的鉴定不稳定，即，生物标志物的选择在很大程度上取决于所分析的样品组，并且使用独立的样品组常常导致完全不同的生物标志物组被鉴定。然而，如果可以鉴定出一组固定的疾病生物标志物用于多种疾病的诊断，则可以降低生物标志物选择的难度。在这项研究中，先前确定的由血液miRNAs组成的通用疾病生物标志物（UDB）可以区分患有多种疾病的患者和健康对照，并扩展到最近报道的血液microRNAs（miRNAs）的独立测量。UDB在一组独立样本中实现的性能与使用lasso（一种标准的高度样本依赖性程序）选择的生物标志物实现的性能具有竞争力。此外，稳定特征提取的发展被认为是构建更有效和稳定的（即，样本和疾病独立）UDB。先前提出的UDB已成功扩展到另外七种疾病，预计将有助于诊断其他疾病。本文的在线版本（doi：10.1186/1756-0500-7-581）包含补充材料，可供授权用户使用。
The selection of disease biomarkers is often difficult because of their unstable identification, i.e., the selection of biomarkers is heavily dependent upon the set of samples analyzed and the use of independent sets of samples often results in a completely different set of biomarkers being identified. However, if a fixed set of disease biomarkers could be identified for the diagnosis of multiple diseases, the difficulties of biomarker selection could be reduced. In this study, the previously identified universal disease biomarker (UDB) consisting of blood miRNAs that could discriminate between patients with multiple diseases and healthy controls was extended to the recently reported independent measurements of blood microRNAs (miRNAs). The performance achieved by UDB in an independent set of samples was competitive with performances achieved with biomarkers selected using lasso, a standard, heavily sample-dependent procedure. Furthermore, the development of stable feature extraction was suggested to be a key factor in constructing more efficient and stable (i.e., sample- and disease-independent) UDBs. The previously proposed UDB was successfully extended to an additional seven diseases and is expected to be useful for the diagnosis of other diseases. The online version of this article (doi:10.1186/1756-0500-7-581) contains supplementary material, which is available to authorized users.