Effects of sedimentation of small red blood cell aggregates on blood flow in narrow horizontal tubes
Effects of sedimentation of small red blood cell aggregates on blood flow in narrow horizontal tubes
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DOI：
10.1016/0006-355x(96)00021-2
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发表时间：
1996-05-01
期刊：
影响因子：
1.1
通讯作者：
Murata, T
中科院分区：
文献类型：
--
作者：
Murata, T
本文用理论模型分析了聚集红细胞悬液在低流速下通过水平管的流动特性，考虑了在较高流速下形成的小聚集体的沉降对相对表观粘度的影响。当悬液中形成大量小聚集体时，由于聚集体的沉积，红细胞似乎以浓缩悬浮液的形式通过试管底部输送，红细胞的分布使用两层流动模型。它由位于管上部的血浆和位于管底部的浓缩红细胞悬浮液组成，两者之间有一光滑的水平界面。假定悬浮液是牛顿流体，其粘度随红细胞压积的增加而呈指数增加。对于不同的放电红细胞压积，计算了速度分布、相对表观粘度和红细胞流量随血浆层宽度的变化。理论计算结果与实验结果进行了比较。在较宽的等离子体层宽度范围内，相对表观粘度随沉降程度的增加而迅速增加。
The flow properties of aggregating red cell suspensions flowing at low flow rates through horizontal tubes are analyzed using a theoretical model, The effects of sedimentation of small aggregates, which will be formed at comparatively high flow rates, on the relative apparent viscosity are considered, In the case in which a large number of small aggregates are formed in a suspension flowing through a horizontal tube, it seems that red cells are transported as a concentrated suspension through the bottom part of the tube because of sedimentation of aggregates, A two-layer flow model is used for the distribution of red cells. It consists of plasma in the upper part and a concentrated red cell suspension in the bottom part of the tube divided by a smooth and horizontal interface, It is assumed that the suspension is a Newtonian fluid whose viscosity increases exponentially with hematocrit, The velocity distribution, the relative apparent viscosity and the flux of red cells are calculated as functions of width of plasma layer for a different discharge hematocrit, The theoretical results are compared with the results obtained from experimental data, The relative apparent viscosity increases rapidly with an increasing degree of sedimentation over a wide range of plasma layer widths.