The carcinogenic potential of the gas phase of environmental tobacco smoke
The carcinogenic potential of the gas phase of environmental tobacco smoke
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DOI：
10.1093/carcin/18.11.2035
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发表时间：
1997-11-01
期刊：
影响因子：
4.7
通讯作者：
Jones, AD
中科院分区：
文献类型：
--
作者：
Witschi, H;Espiritu, I;Jones, AD
将雌性A/J系小鼠暴露于未过滤或HEPA过滤的环境烟草烟雾（ETS）中，全烟雾暴露室中的总悬浮颗粒物（TSP）为78.5 mg/m3，过滤烟雾室中的TSP为0.1 mg/m3;全烟雾室和过滤烟雾室中的尼古丁浓度分别为13.4和3.1 mg/m3。暴露于过滤ETS的动物（每天6小时，每周5天）并在5个月后处死的动物的肺肿瘤发病率和多样性高于保持在过滤空气中的对照组，尽管差异没有统计学显著性。暴露于空气的对照动物的平均肿瘤多样性为每肺0.5 +/-0.1个肿瘤。在暴露于过滤烟雾的动物的肺中，增加的免疫染色对于EST 1A 1是不明显的。基于所选亚硝胺和多环芳烃的室浓度，在5个月暴露期内小鼠对NNK、NNN和苯并[a]芘的可能最大摄取量比文献中报道的在A/J品系小鼠中产生1个肺肿瘤的剂量低3至6个数量级。得出的结论是，气相ETS与全ETS一样具有致癌性，气相的致癌性可能是由于一些尚未确定的但高度有效的致癌物或通过对肺施加大量的可能是自由基介导的氧化应激。
Female strain A/J mice were exposed to unfiltered or HEPA-filtered environmental tobacco smoke (ETS), Total suspended particulates (TSP) in the full smoke exposure chamber was 78.5 mg/m(3) and in the filtered smoke chamber 0.1 mg/m(3); nicotine concentrations in the full and filtered smoke chamber were 13.4 and 3.1 mg/m(3), respectively. Animals exposed to filtered ETS (6 h a day, 5 days a week) and killed after 5 months had a higher lung tumor incidence and multiplicity than controls maintained in filtered air, although the differences were not statistically significant, Animals exposed to filtered and full ETS and allowed to recover in air for 4, months had an average of 1.2 +/- 0.3 tumors per lung and 1.3 +/- 0.3 tumors per lung, respectively, Air exposed control animals had an average tumor multiplicity 0.5 +/- 0.1 tumors per lung. Increased immunstaining for CYP 1A1 was not evident in the lung of animals exposed to filtered smoke. Based on the chamber concentrations of selected nitrosamines and polycyclic aromatic hydrocarbons, the possible maximum uptakes by the mice of NNK, NNN and benzo[a]pyrene during the 5 months exposure period were three to six orders of magnitude below doses reported in the literature to produce 1 lung tumor in strain A/J mice, It was concluded that the gas phase of ETS is as carcinogenic as is full ETS, The carcinogenicity of the gas phase may be due to some as yet unidentified, yet highly potent carcinogens or by placing a substantial, possibly free radical-mediated oxidative stress on the lung.