Reactive oxygen species, cell signaling, and cell injury
Reactive oxygen species, cell signaling, and cell injury
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DOI：
10.1016/s0891-5849(00)00252-5
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发表时间：
2000-05-15
影响因子：
7.4
通讯作者：
Floyd, RA
中科院分区：
文献类型：
--
作者：
Hensley, K;Robinson, KA;Floyd, RA
传统上，氧化应激被视为有氧代谢引起的细胞损伤的随机过程，而抗氧化剂被简单地视为自由基清除剂。直到最近，人们才认识到活性氧（ROS）被广泛用作第二信使来传播促炎或生长刺激信号。有了这些知识，我们就必然认识到氧化应激和慢性炎症是相关的，甚至是不可分割的现象。旨在补充抗氧化防御系统同时拮抗氧化还原敏感信号转导的新药理学策略可能会改善慢性炎症或退行性疾病（包括阿尔茨海默病）的临床管理，将抗氧化疗法引入主流医学是可能且有希望的，但需要基础细胞生物学、药理学和临床生物分析方面的重大进展。 (C) 2000 爱思唯尔科学公司。
Oxidative stress has traditionally been viewed as a stochastic process of cell damage resulting from aerobic metabolism, and antioxidants have been viewed simply as free radical scavengers. Only recently has it been recognized that reactive oxygen species (ROS) are widely used as second messengers to propagate proinflammatory or growth-stimulatory signals. With this knowledge has came the corollary realization that oxidative stress and chronic inflammation are related, perhaps inseparable phenomena. New pharmacological strategies aimed at supplementing antioxidant defense systems while antagonizing redox-sensitive signal transduction may allow improved clinical management of chronic inflammatory or degenerative conditions, including Alzheimer's disease, introduction of antioxidant therapies into mainstream medicine is possible and promising, but will require significant advances in basic cell biology, pharmacology, and clinical bioanalysis. (C) 2000 Elsevier Science Inc.