CAMPYLOBACTER-PYLORIDIS AND GASTRITIS - ASSOCIATION WITH INTERCELLULAR SPACES AND ADAPTATION TO AN ENVIRONMENT OF MUCUS AS IMPORTANT FACTORS IN COLONIZATION OF THE GASTRIC EPITHELIUM
CAMPYLOBACTER-PYLORIDIS AND GASTRITIS - ASSOCIATION WITH INTERCELLULAR SPACES AND ADAPTATION TO AN ENVIRONMENT OF MUCUS AS IMPORTANT FACTORS IN COLONIZATION OF THE GASTRIC EPITHELIUM
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DOI：
10.1093/infdis/153.4.658
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发表时间：
1986-04-01
影响因子：
6.4
通讯作者：
HENNESSY, W
中科院分区：
文献类型：
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作者：
HAZELL, SL;LEE, A;HENNESSY, W
通过光学和电子显微镜检查来自> 40个患有幽门弯曲杆菌相关性胃炎的个体的胃活检标本。细菌始终出现在两个位置：胃粘液内和胃上皮细胞的细胞间连接处。C.幽门螺旋杆菌被认为是适应肠粘液提供的特殊生态位的一大群螺旋细菌之一。这些生物的螺旋形态和运动形式使它们在粘性环境中具有选择性优势。这一点已经在体外通过测量临床分离株在不同粘度的甲基纤维素溶液中的速度得到证实。C.接近细胞间连接的幽门螺杆菌被认为是由于生长因子的优选代谢物的存在，例如，尿素和氯化血红素。所有分离株都表现出极高的脲酶活性，并需要氯化血红素生长。
Stomach biopsy specimens from > 40 individuals with Campylobacter yloridis-associated gastritis were examined by light and electron microscopy. The bacteria were consistently seen in two locations: within the gastric mucus and associated with intercellular junctions of gastric epithelial cells. C. pyloridis is suggested to be one of a broad group of spiral bacteria that are adapted to the peculiar niche provided by intestinal mucus. The spiral morphology and the form of motility of these organisms give them a selective advantage in a viscous environment. This point has been demonstrated in vitro by measurement of the velocity of clinical isolates in solutions of methyl cellulose of varying viscosity. The loalizaton of C. pyloridis close to intercellular junctions is proposed to be due to the presence of preferred metabolites of growth factors, e.g., urea and hemin. All isolates show an extremely high urease activity and require hemin for growth.