Mental work demands protect against cognitive impairment: MAAS prospective cohort study
Mental work demands protect against cognitive impairment: MAAS prospective cohort study
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DOI：
10.1080/03610730303710
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发表时间：
2003-01-01
影响因子：
1.8
通讯作者：
Jolles, J
中科院分区：
文献类型：
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作者：
Bosma, H;van Boxtel, MPJ;Jolles, J
对于从事脑力劳动的人是否能够免受认知障碍以及这种关联是否独立于智力和其他混杂因素，人们知之甚少。马斯特里赫特老龄化研究 (MAAS) 的纵向数据被用来检验这种关联。 1993年至1995年基线检查后，对630名年龄在50岁至80岁之间的男性和女性进行了第一次为期3年的随访检查（1996年至1998年），他们在基线时没有表现出认知障碍。与没有此类工作的人相比，从事脑力要求高的工作的人在随访期间发生认知障碍的风险较低（36 例）（比值比 = 0.79；95% 置信区间：0.65-0.96）。大约 1.5% 的脑力工作要求高的人出现了障碍，而工作要求低的人中这一比例为 4%。保护作用与智力和其他混杂因素无关。我们的研究结果提供了证据，表明成年期间持续且可能可改变的精神刺激可以保护男性和女性免受认知障碍。
Little is known about whether persons with mentally demanding jobs are protected against cognitive impairment and whether this association is independent of intellectual abilities and other confounders. Longitudinal data from the Maastricht Aging Study (MAAS) were used to examine this association. After the 1993 - 1995 baseline examination, there was a first 3-year follow-up examination ( 1996 - 1998) among 630 men and women, aged 50 to 80, who exhibited no cognitive impairment at baseline. Persons with mentally demanding jobs had lower risks of developing cognitive impairment during follow-up ( 36 cases), compared with persons without such jobs ( odds ratio = 0.79; 95% confidence interval: 0.65-0.96). About 1.5% of the persons with high mental work demands developed impairment compared to 4% of the persons with few work demands. The protective effect was independent of intellectual abilities and other confounders. Our findings provide evidence that continued and potentially modifiable mental stimulation during adult life may protect men and women against cognitive impairment.