The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium
The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium
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DOI：
10.1016/j.neubiorev.2017.09.002
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发表时间：
2018-02-01
影响因子：
8.2
通讯作者：
Gerlai, Robert
中科院分区：
文献类型：
--
作者：
Shams, Soaleha;Rihel, Jason;Gerlai, Robert
斑马鱼代表了系统复杂性和实际简单性之间的一个很好的折衷，这些特征使其对复杂大脑疾病的建模和机制分析非常有用。同样有希望的是筛选对斑马鱼幼体和成体行为有影响的精神活性药物。这篇综述基于最近在2016年IBNS大会上举行的研讨会，就如何利用斑马鱼推进人类中枢神经系统疾病的研究提供了不同的观点。它开始讨论在斑马鱼研究的一个重要瓶颈，测量这个物种的行为（特别是浅滩），并继续与自闭症谱系障碍的研究在幼斑马鱼，在筛选天然产品的化合物与精神活性在成年斑马鱼，并在胎儿酒精谱系障碍的斑马鱼模型的发展的例子。通过提供有关广泛的脑疾病，实验方法和科学方法，使用幼虫和成年斑马鱼的信息，审查的目的是展示这种未充分利用的实验室物种的行为神经科学和精神药理学研究。
The zebrafish represents an excellent compromise between system complexity and practical simplicity, features that make it useful for modeling and mechanistic analysis of complex brain disorders. Also promising are screens for psychoactive drugs with effects on larval and adult zebrafish behavior. This review, based upon a recent symposium held at the 2016 IBNS Congress, provides different perspectives on how the zebrafish may be utilized to advance research into human central nervous system disorders. It starts with a discussion on an important bottleneck in zebrafish research, measuring the behavior of this species (specifically shoaling), and continues with examples on research on autism spectrum disorder in larval zebrafish, on screening natural products for compounds with psychoactive properties in adult zebrafish, and on the development of a zebrafish model of fetal alcohol spectrum disorders. By providing information on a broad spectrum of brain disorders, experimental methods, and scientific approaches using both larval and adult zebrafish, the review is intended to showcase this underutilized laboratory species for behavioral neuroscience and psychopharmacology research.