Comparison of buprenorphine and methadone in the treatment of opioid dependence.
Comparison of buprenorphine and methadone in the treatment of opioid dependence.
复制标题
丁丙诺啡和美沙酮治疗阿片类药物依赖的比较。
DOI：
10.1176/ajp.151.7.1025
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Bigelow,GE
中科院分区：
文献类型：
--
作者：
Strain,EC;Stitzer,ML;Liebson,IA;Bigelow,GE
本研究比较了丁丙诺啡和美沙酮在治疗阿片类药物dependence.MethodParticipants（N= 164）的疗效相对治疗幼稚，阿片类药物依赖的申请人26周的治疗计划谁被随机分配到美沙酮或丁丙诺啡治疗。给药为双盲和双模拟。患者在美沙酮50 mg或丁丙诺啡8 mg方案下稳定，治疗第16周可能会改变剂量。尿样收集每周三次，每周咨询provided.ResultsBuprenorphine（平均剂量= 8.9毫克/天）和美沙酮（平均剂量= 54毫克/天）是同样有效的维持保留治疗，药物治疗的依从性，和咨询方案。在两组中，56%的患者在16周的灵活给药期内仍在接受治疗。丁丙诺啡和美沙酮组的总体阿片类药物阳性尿样率分别为55%和47%;可卡因阳性尿样率分别为70%和58%。证据是在抑制阿片类药物，但不是可卡因，使用那些谁收到的剂量increases.ConclusionsThe结果的效用丁丙诺啡作为一种新的药物在阿片类药物依赖的治疗提供了进一步的支持，并证明疗效相当于美沙酮时，在临床指导灵活的给药程序。
ObjectiveThis study compared the efficacy of buprenorphine and methadone in the treatment of opioid dependence.MethodParticipants (N= 164) were relatively treatment-naive, opioid-dependent applicants to a 26-week treatment program who were randomly assigned to either methadone or buprenorphine treatment. Dosing was double-blind and double-dummy. Patients were stabilized on a regimen of either methadone, 50 mg, or buprenorphine, 8 mg, with dose changes possible through week 16 of treatment. Urine samples were collected three times a week, and weekly counseling was provided.ResultsBuprenorphine (mean dose= 8.9 mg/day) and methadone (mean dose= 54 mg/day) were equally effective in sustaining retention in treatment, compliance with medication, and counseling regimens. In both groups, 56% of patients remained in treatment through the 16-week flexible dosing period. Overall opioid-positive urine sample rates were 55% and 47% for buprenorphine and methadone groups, respectively; cocaine-positive urine sample rates were 70% and 58%. Evidence was obtained for the effectiveness of dose increases in suppressing opioid, but not cocaine, use among those who received dose increases.ConclusionsThe results of this study provide further support for the utility of buprenorphine as a new medication in the treatment of opioid dependence and demonstrate efficacy equivalent to that of methadone when used during a clinically guided flexible dosing procedure.