Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task
Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task
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DOI：
10.1016/s0166-4328(01)00399-0
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发表时间：
2002-04-15
影响因子：
2.7
通讯作者：
Sutherland, RJ
中科院分区：
文献类型：
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作者：
Astur, RS;Taylor, LB;Sutherland, RJ
对于非人类，已经表明海马体（HPC）对空间记忆至关重要。我们对单侧HPC切除的患者进行了一项经典空间任务的虚拟模拟，以评估HPC在非人类中的功能：Morris水任务。我们发现，当人类被要求使用空间线索导航到游泳池中隐藏的逃生平台时。相对于年龄匹配的对照组和年龄匹配的已进行额外HPC切除的患者，HPC切除的患者在空间导航方面显示出严重的障碍。这种影响发生在每一个受试患者身上，无论手术侧如何都是明显的。因此，很明显，在不同物种中，无论哪个半球受损，人类HPC对空间/关系记忆至关重要。(C)2002 Elsevier Science B. V.保留所有权利。
For nonhumans, it has been shown that the hippocampus (HPC) is critical for spatial memory. We tested patients with unilateral HPC resections on a virtual analogue of a classic spatial task to assess HPC functioning in nonhumans: the Morris water task. We found that when humans are required to use spatial cues to navigate to a hidden escape platform in a pool. patients with HPC resections display severe impairments in spatial navigation relative to age-matched controls and age-matched patients who have had extra-HPC resections. This effect occurred for every patient tested and was evident regardless of side of surgery. Hence, it is apparent across species and irrespective of which hemisphere is damaged that the human HPC is critical for spatial/relational memory. (C) 2002 Elsevier Science B.V. All rights reserved.