Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.
Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.
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DOI：
10.1084/jem.141.6.1365
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发表时间：
1975-06-01
期刊：
影响因子：
--
通讯作者：
Seybold ME
中科院分区：
文献类型：
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作者：
Lennon VA;Lindstrom JM;Seybold ME
用来自电鳐和加利福尼亚电鳐的电器官的乙酰胆碱受体（AChR）蛋白免疫动物，诱导对哺乳动物骨骼肌的AChR的自身免疫应答。大鼠和豚鼠在单次接种少量AChR和佐剂后发生实验性自身免疫性重症肌无力（EAMG）。疾病的发病率和严重程度似乎取决于AChR的剂量和乳剂的稳定性。EAMG与人类重症肌无力（MG）在临床表现和电生理异常方面有着惊人的相似性。EAMG大鼠血清中存在抗同基因大鼠肌肉AChR抗体，证明了实验性疾病中存在自身免疫。提示EAMG和MG有共同的免疫发病机制。
Immunization of animals with acetylcholine receptor (AChR) protein from the electric organs of Electrophorus electricus and Torpedo californica induces an autoimmune response to the AChR of mammalian skeletal muscle. Rats and guinea pigs develop experimental autoimmune myasthenia gravis (EAMG) after a single inoculation with small quantities of AChR and adjuvant. The indicence and severity of disease appears to depend on the dose of AChR and stability of the emulsion. EAMG is strikingly similar to myasthenia gravis (MG) of man in its clinical picture and its electrophysiological abnormalities. The presence of antibodies to syngeneic rat muscle AChR in the serum of rats with EAMG documents the existence of autoimmunity in the experimental disease. A common immunopathogenesis is suggested for both EAMG and mg.