STATs and MAPKs: Obligate or opportunistic partners in signaling
STATs and MAPKs: Obligate or opportunistic partners in signaling
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DOI：
10.1002/bies.950180204
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发表时间：
1996-02-01
期刊：
影响因子：
4
通讯作者：
Ihle, JN
中科院分区：
文献类型：
--
作者：
Ihle, JN
配体与细胞受体的结合启动了一系列信号转导级联反应，这是细胞反应所必需的。Ras通路响应于多种配体而被激活，并已被广泛研究。最近，一个新的转录因子家族（Stats）已被发现在响应许多配体时被激活。最近发表的三篇文章（1-3）提供了证据，表明这两种途径在通过MAP激酶磷酸化调节Stat功能的水平上汇合。然而，每个人都提出了截然不同的模型，这些模型不容易调和，但需要进一步的实验。
Ligand binding to cellular receptors initiates a series of signal transducing cascades that are essential to cellular responses. The Ras pathway is activated in response to a variety of ligands and has been extensively studied. More recently, a novel family of transcription factors (Stats) has been found to be activated in response to many ligands. Three recent publications((1-3)) have presented evidence to suggest that these two pathways converge at the level of modulation of Stat function by phosphorylation by MAP kinases. However, each proposes radically different models that are not easily reconciled but invite further experimentation.