AN ANTIBODY CYTO-TOXIC TO MEGAKARYOCYTE PROGENITOR CELLS IN A PATIENT WITH IMMUNE THROMBOCYTOPENIC PURPURA
AN ANTIBODY CYTO-TOXIC TO MEGAKARYOCYTE PROGENITOR CELLS IN A PATIENT WITH IMMUNE THROMBOCYTOPENIC PURPURA
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DOI：
10.1056/nejm198505023121807
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
PRCHAL, JT
中科院分区：
文献类型：
--
作者：
HOFFMAN, R;ZAKNOEN, S;PRCHAL, JT
慢性特发性血小板减少性紫癜是一种以血小板数量减少和骨髓巨核细胞数量正常或增加引起的出血为特征的综合征。这种疾病中的血小板减少症是由于针对血小板抗原的IgG抗体引起的。这些抗体的存在最终导致血小板被网状内皮系统破坏。1，2 McKenna和Pisciotta 3以及McMillan及其同事4提供的证据表明，这些抗体也与骨髓巨核细胞反应。然而，这些抗体对体内血小板生成的影响尚不清楚。Harker 5和Branehög等6发现，特发性血小板减少症患者血小板更新率增加。
Chronic idiopathic thrombocytopenic purpura is a syndrome characterized by bleeding due to a reduced number of platelets and normal or increased numbers of marrow megakaryocytes. The thrombocytopenia in this disorder is due to IgG antibodies that are directed against platelet antigens. The presence of these antibodies eventually results in platelet destruction by the reticuloendothelial system.1,2McKenna and Pisciotta3and McMillan and co-workers4have provided evidence that these antibodies also react with marrow megakaryocytes. The effect of these antibodies on in vivo thrombopoiesis, however, is unknown. Harker5and Branehög et al.6have found that platelet turnover is increased in idiopathic thrombocytopenic . . .