Longitudinal associations between metabolic score for visceral fat and hyperuricemia in non-obese adults
Longitudinal associations between metabolic score for visceral fat and hyperuricemia in non-obese adults
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DOI：
10.1016/j.numecd.2020.06.001
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发表时间：
2020-09-24
影响因子：
3.9
通讯作者：
Fan, Jie
中科院分区：
文献类型：
--
作者：
Liu, Xing Z.;Chen, Dong S.;Fan, Jie
背景和目的：内脏肥胖症的评估对于预防高尿酸血症(HUA)，特别是非肥胖者具有重要意义。内脏脂肪代谢评分(METS-VF)是一种新提出的内脏肥胖替代指标。我们旨在评估Mets-VF与非肥胖者发生华氏综合症风险的纵向关联。方法和结果：共纳入16,058例非肥胖者，进行回顾性队列分析。非肥胖女性HUA粗发病率为20.9/1000人年，男性为69.6/1000人年。Cox比例风险模型显示，无论男女，Mets-VF均与HUA的风险显著相关。结论：Mets-VF是一种结合生化和人体测量参数、年龄和性别的新型内脏肥胖症代用品，可作为分级预防和管理非肥胖女性HUA的有效工具。(C)2020年意大利糖尿病学会、意大利动脉粥样硬化研究学会、意大利人类营养学会和费德里科二世大学临床内外科。爱思唯尔出版，版权所有。
Background and aims: The assessment of visceral adiposity is of great significance for the prevention of hyperuricemia (HUA), especially in non-obese individuals. The metabolic score for visceral fat (METS-VF) is a newly proposed surrogate of visceral obesity. We aimed to evaluate the longitudinal associations of METS-VF with the risk of HUA in non-obese adults.Methods and results: A total of 16,058 non-obese adults without HUA were included for this retrospective cohort analyses. The crude incidence rate of HUA in non-obese women and men were 20.9 and 69.6 per 1000 person-years, respectively. The Cox proportional hazards model indicated that METS-VF was significantly associated with the risk of HUA in both genders. Whereas, METS-VF only had the highest HR in women, but not in men.Conclusions: METS-VF, a novel surrogate of visceral adiposity combined biochemical and anthropometric parameters, age, and gender, could be a useful tool for the hierarchical prevention and management of HUA among non-obese women. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.