The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation
The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation
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DOI：
10.1111/j.1365-2796.2006.01685.x
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发表时间：
2006-09-01
影响因子：
11.1
通讯作者：
Chandler, J.
中科院分区：
文献类型：
--
作者：
Lips, P.;Hosking, D.;Chandler, J.
介绍。维生素 D 对于钙代谢和预防骨折至关重要，最近的一项综述表明，最佳血清 25(OH)D 浓度在 50-80 nmol L-1 (20-32 ng mL(-1)) 范围内。许多研究报告了骨质疏松症的高患病率，但世界不同地区骨质疏松症女性骨质疏松症的患病率尚未得到很好的描述。背景和受试者。 2004 年和 2005 年对不同纬度（范围 64N-38S）的 18 个国家进行了一项跨国研究，以确定血清 25(OH)D 的平均水平和维生素 D 不足的发生率。共有 2606 名患有骨质疏松症（骨矿物质密度低、有脆性骨折史）寻求常规医疗护理的绝经后妇女入组，并在单次实验室就诊时测量了血清 25(OH)D 水平。 结果。平均血清25(OH)D水平为26.8 ng mL(-1) (SE 0.3)，范围为7至243 ng mL(-1)。拉丁美洲的区域平均值最高（29.6 ng mL(-1)，SE 0.6），中东最低（20.4 ng mL(-1)，SE 0.5）。总体而言，64% 的女性血清水平< 30 ng mL(-1)。血清甲状旁腺激素在血清25(OH)D水平>35 ng mL(-1)时达到最低点。在非赤道国家，冬季招募的女性血清 25(OH)D 水平略低于一些国家（但并非全部）夏季招募的女性。结论。血清 25(OH)D 水平低在患有骨质疏松症的女性中很常见。结果强调了确保这些女性维生素 D 充足的价值。
Introduction. Vitamin D is essential for calcium metabolism as well as for fracture prevention, and a recent review suggested that the optimal serum 25(OH)D lies in the region of 50-80 nmol L-1 (20-32 ng mL(-1)). A high prevalence of inadequacy has been reported in many studies but the prevalence of inadequacy amongst women with osteoporosis in different regions of the world has not been well characterized.Setting and subjects. A multinational study of 18 countries at various latitudes (range 64N-38S) was conducted in 2004 and 2005 to determine the average levels of serum 25(OH)D and the prevalence of vitamin D inadequacy. A total of 2606 postmenopausal women with osteoporosis (low bone mineral density, history of fragility fracture) seeking routine medical care were enrolled and serum 25(OH)D levels were measured at a single laboratory visit.Results. Mean serum 25(OH)D level was 26.8 ng mL(-1) (SE 0.3) and ranged from 7 to 243 ng mL(-1). Regional mean values were highest in Latin America (29.6 ng mL(-1), SE 0.6) and lowest in the Middle East (20.4 ng mL(-1), SE 0.5). Overall, 64% of women had serum levels < 30 ng mL(-1). Serum parathyroid hormone reached a nadir at serum 25(OH)D levels > 35 ng mL(-1). In nonequatorial countries, women recruited during the winter months had somewhat lower serum 25(OH)D levels than those recruited during the summer months in some, but not all, countries.Conclusions. Low levels of serum 25(OH)D are common amongst women with osteoporosis. The results underscore the value of assuring vitamin D adequacy in these women.