The combination of Helicobacter pylori- and cytotoxin-associated gene-A seropositivity in relation to the risk of myocardial infarction in middle-aged Japanese: The Japan Public Health Center-based study
The combination of Helicobacter pylori- and cytotoxin-associated gene-A seropositivity in relation to the risk of myocardial infarction in middle-aged Japanese: The Japan Public Health Center-based study
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DOI：
10.1016/j.atherosclerosis.2013.06.013
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发表时间：
2013-09-01
期刊：
影响因子：
5.3
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Ikeda, Ai;Iso, Hiroyasu;Tsugane, Shoichiro
背景：关于幽门螺杆菌（h.p ylori）和细胞毒素相关基因a （CagA）联合阳性对心肌梗死（MI）和中风风险的影响的证据有限，特别是在幽门螺杆菌感染率高的亚洲人群中。方法：对29,876名年龄在40-69岁、无心脏病、中风或癌症史的男性和女性进行了一项前瞻性巢式病例对照研究，以检查幽门螺杆菌和CagA与心肌梗死和中风风险之间的关系。参与者在1990年至1994年间完成了一项风险因素调查并捐献了血液样本。2002年进行了系统的心血管监测。根据性别、年龄、采血日期、最后一餐后的时间和研究地点对每例脑卒中患者和每例心肌梗死患者分别进行对照和对照。结果：随访期间共发生卒中600例，心肌梗死106例。H. pylori-IgG阳性与心肌梗死风险无相关性，而CagA阳性与心肌梗死风险有相关性（OR = 1.72, 95%CI: 0.91-3.26, p = 0.10）。我们没有发现幽门螺杆菌或CagA与中风风险之间的联系。结论：幽门螺杆菌感染与中年日本人心肌梗死和中风风险无显著相关。然而，CagA阳性倾向于与MI相关。(C) 2013 Elsevier Ireland Ltd。版权所有。
Background: Limited evidence is available concerning the impact of the combination of Helicobacter pylori- (H. pylori) and cytotoxin-associated gene-A (CagA)-positivity on the risk of myocardial infarction (MI) and stroke, particularly in Asian populations, in which the prevalence of H. pylori infection is high.Methods: A prospective, nested case-control study was conducted to examine the association between H. pylori and CagA and risk of MI and stroke within a cohort of 29,876 men and women aged 40-69 years with no history of heart disease, stroke or cancer. Participants completed a risk factor survey and donated blood samples between 1990 and 1994. Systematic cardiovascular surveillance was performed through 2002. One control for each stroke case and two controls for each MI case were matched by sex, age, date of blood sampling, time since last meal and study location.Results: During the follow-up period, there were 600 strokes and 106 MIs. H. pylori-IgG positivity was not associated with the risk of MI, while CagA positivity tended to be associated with it (OR = 1.72, 95%CI: 0.91-3.26, p = 0.10). We found no association between H. pylori or CagA and risk of stroke.Conclusions: H. pylori infection was not significantly associated with risk of MI and stroke among middle-aged Japanese. However, CagA positivity tended to be associated with MI. (C) 2013 Elsevier Ireland Ltd. All rights reserved.