Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders
Serum pentadecanoic acid (15:0), a short-term marker of dairy food intake, is inversely associated with incident type 2 diabetes and its underlying disorders
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DOI：
10.3945/ajcn.114.092544
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发表时间：
2014-12-01
影响因子：
7.1
通讯作者：
Hanley, Anthony J.
中科院分区：
文献类型：
--
作者：
Santaren, Ingrid D.;Watkins, Steven M.;Hanley, Anthony J.
背景：越来越多的证据表明，乳制品消费与降低2型糖尿病风险有关。然而，观察性研究报告了不一致的结果，很少有人研究乳制品与胰岛素抵抗和β细胞功能障碍的潜在疾病之间的关系。目的：我们研究了乳制品脂肪酸生物标志物五酸（15:0）和反式棕榈油酸（16:1 n-7）与2型糖尿病特征的关系，通过评估1)随访5年后与糖尿病发生率的前瞻性关联，以及2)与直接测量的胰岛素抵抗和β细胞功能障碍的横断相关性。设计：本研究分析了来自三种族多中心胰岛素抵抗动脉粥样硬化研究（IRAS）的659名无糖尿病的成人。通过口服葡萄糖耐量试验评估糖尿病状态。经常取样的静脉葡萄糖耐量试验测量胰岛素敏感性（S-1）和β细胞功能[处置指数（DI）]。采用气相色谱法测定血清脂肪酸含量。根据人口统计学、生活方式和饮食变量调整Logistic和线性回归模型。结果：血清15:0是IRAS队列中乳制品总摄入量的重要生物标志物。在完全调整后的模型中，它与降低糖尿病发生风险相关（OR: 0.73, P = 0.02），并与log S-1 （beta: 0.84, P = 0.03）和log DI （beta: 2.21, P = 0.02）呈正相关。Trans 16:1n-7是部分氢化膳食脂肪总摄入量的标志，与完全调整模型的结果无关。结论：在这个多种族队列中，血清15:0是短期摄入这种脂肪酸的标志，与糖尿病风险呈负相关。这项研究可能有助于未来关于乳制品对2型糖尿病风险的益处的建议。
Background: Growing evidence suggests that dairy consumption is associated with lower type 2 diabetes risk. However, observational studies have reported inconsistent results, and few have examined dairy's association with the underlying disorders of insulin resistance and beta-cell dysfunction.Objective: We investigated the association of the dairy fatty acid biomarkers pentadecanoic acid (15:0) and trans-palmitoleic acid (trans 16: 1 n-7) with type 2 diabetes traits by evaluating 1) prospective associations with incident diabetes after 5 y of follow-up and 2) cross-sectional associations with directly measured insulin resistance and beta-cell dysfunction.Design: The study analyzed 659 adults without diabetes at baseline from the triethnic multicenter Insulin Resistance Atherosclerosis Study (IRAS). Diabetes status was assessed by using oral-glucose-tolerance tests. Frequently sampled intravenous-glucose-tolerance tests measured insulin sensitivity (S-1) and beta-cell function [disposition index (DI)]. Serum fatty acids were quantified by using gas chromatography. Logistic and linear regression models were adjusted for demographic, lifestyle, and dietary variables.Results: Serum 15:0 was a significant biomarker for total dairy intake in the IRAS cohort. It was associated with a decreased incident diabetes risk (OR: 0.73, P = 0.02) and was positively associated with log S-1 (beta: 0.84, P = 0.03) and log DI (beta: 2.21, P = 0.02) in fully adjusted models. trans 16:1n-7 was a marker of total partially hydrogenated dietary fat intake and was not associated with outcomes in fully adjusted models.Conclusions: Serum 15:0, a marker of short-term intake of this fatty acid, was inversely associated with diabetes risk in this multiethnic cohort. This study may contribute to future recommendations regarding the benefits of dairy products on type 2 diabetes risk.