QUANTITATIVE SUDOMOTOR AXON REFLEX TEST IN NORMAL AND NEUROPATHIC SUBJECTS
QUANTITATIVE SUDOMOTOR AXON REFLEX TEST IN NORMAL AND NEUROPATHIC SUBJECTS
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DOI：
10.1002/ana.410140513
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发表时间：
1983-01-01
影响因子：
11.2
通讯作者：
DYCK, PJ
中科院分区：
文献类型：
--
作者：
LOW, PA;CASKEY, PE;DYCK, PJ
使用乙酰胆碱电泳检查了由轴突反射刺激引起的人类受试者的节后汗液输出。使除湿N2控制的温度和流速通过放置在皮肤的限定区域上的丙烯酸塑料室。汗滴蒸发;湿度变化由装在温度控制室中的窄范围湿度传感器感测，并在图表记录器上绘制。对时间积分（曲线下面积）进行连续积分，并使用推导公式转换为绝对单位。由于刺激和记录是同时进行的，因此也可以准确确定汗液反应的潜伏期。对33名女性和29名男性11-69岁正常人的左前臂和左足进行了定量的催汗轴突反射试验。10%乙酰胆碱在前臂和足部分别记录5 mA-min和10 mA-min，并继续记录5 min。男性前臂和足部的平均出汗量分别是女性的2.7和3.0倍（P < 0.0001）。在选定的自主神经病变的研究证实，定量催汗轴突反射测试将检测节后催汗异常敏感和可重复性。
Postganglionic sweat output was examined in human subjects resulting from axon reflex stimulation using acetylcholine electrophoresis. Dehumidified N2 controlled temperature and flow rate was passed through an acrylic plastic chamber placed over a defined area of skin. Sweat droplets were evaporated; humidity change was sensed by a narrow-range humidity sensor housed in a temperature-controlled compartment and was plotted on a chart recorder. The time integral (area under the curve) was continuously integrated and converted to absolute units using a derived equation. Because stimulation and recording were simultaneous, an accurate determination of the latency of the sweat response was also possible. Quantitative sudomotor axon reflex tests were performed on the left forearm and foot of 33 female and 29 male normal subjects aged 11-69 yr. Acetylcholine, 10%, was electrophoresed for 5 mA-min in the forearm and 10 mA-min in the foot, and recording was continued for an additional 5 min. The mean sweat output in males was 2.7 and 3.0 times that in females in forearm and foot, respectively (P < 0.0001). Studies in selected autonomic neuropathies confirm that quantitative sudomotor axon reflex tests will detect postganglionic sudomotor abnormalities sensitively and reproducibly.