Cerebrospinal fluid - physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases
Cerebrospinal fluid - physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases
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DOI：
10.1177/135245859800400302
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发表时间：
1998-06-01
期刊：
影响因子：
--
通讯作者：
Reiber, H
中科院分区：
文献类型：
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作者：
Reiber, H
本文回顾了脑脊液常规分析的最新进展，特别是多发性硬化症。(1)以脑脊液流速为主要调节因子的血-脑脊液屏障功能和功能障碍的生理学和病理生理学；(2)神经免疫学方面：(A)实际Reiber图中疾病相关免疫球蛋白类反应(Ig G、Ig A、Ig M)的模式，参考特定参数和可选试验，以及(B)脑内寡克隆、多特异性抗体的合成；(3)脑脊液和血液中的特殊标志物蛋白用于神经系统疾病的鉴别诊断；(4)数学玻色法用于评价脑脊液数据，并以一例多发性硬化症患者为例，计算鞘内免疫球蛋白和抗体合成以及抗体指数。
The state of the art in routine CSF analysis is reviewed with particular reference to multiple sclerosis regarding. (1) The physiology and pathophysiology of blood-CSF barrier function and dysfunction with the CSF flow rate as main modulator of blood- and brain-derived protein concentrations in CSF; (2) The neuroimmunological aspects regarding (a) patterns of disease-related immunoglobulin class response (IgG, IgA, IgM) in actual Reiber graphs with reference to specific parameters and optional tests, and (b) the oligoclonal, polyspecific antibody synthesis in brain; (3) Particular marker proteins in CSF and blood for differential diagnosis of neurological diseases, (4) Mathematical bose for evaluations of CSF data with on example of a multiple sclerosis patient for calculation of intrathecal immunoglobulin and antibody synthesis as well as Antibody Index.