Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus vulgaris
Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus vulgaris
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DOI：
10.1111/j.1365-2133.2006.07305.x
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发表时间：
2006-08-01
影响因子：
10.3
通讯作者：
Tamaki, K.
中科院分区：
文献类型：
--
作者：
Asashima, N.;Fujimoto, M.;Tamaki, K.
BAFF [属于肿瘤坏死因子 (TNF) 家族的 B 细胞激活因子] 是调节 B 淋巴细胞增殖和存活的 TNF 超家族的成员。已证明，可溶性 BAFF 水平升高与系统性红斑狼疮、类风湿性关节炎和干燥综合征患者以及自发性自身免疫性疾病动物模型中的系统性自身免疫相关。然而，循环 BAFF 在自身免疫性大疱性疾病中的意义尚不清楚。为了检查 BAFF 水平在自身免疫性水疱性疾病寻常型天疱疮 (PV) 和大疱性类天疱疮 (BP) 中是否升高。我们检测了从 21 名 PV 患者、39 名 BP 患者和 22 名健康供者获得的血清。我们对可溶性 BAFF 和每种疾病特异性抗体进行了酶联免疫吸附测定：针对 PV 的抗桥粒芯糖蛋白 3 抗体和针对 BP 的抗 BP180 抗体。在 BP 患者中发现血清 BAFF 水平显着升高，但在 PV 患者中没有发现。 BP患者血清BAFF水平与抗BP180抗体滴度之间显然没有显着相关性。然而，病程较短的患者血清 BAFF 水平往往更高。有一种趋势是，在 BP 发病时，BAFF 水平先于抗 BP180 抗体水平升高，并在治疗后迅速降低。BAFF 可能是自身免疫素质早期激活的有用标记，并且可能在触发 BP 中自身抗原驱动的自身反应性 B 细胞激活中发挥关键作用。
BAFF [B-cell activating factor belonging to the tumour necrosis factor (TNF) family] is a member of the TNF superfamily that regulates B-lymphocyte proliferation and survival. It has been demonstrated that increased levels of soluble BAFF are associated with systemic autoimmunity in patients with systemic lupus erythematosus, rheumatoid arthritis and Sjogren's syndrome, and in animal models of spontaneous autoimmune diseases. However, the significance of circulating BAFF in autoimmune bullous diseases is unknown.To examine whether BAFF levels are elevated in the autoimmune blistering diseases pemphigus vulgaris (PV) and bullous pemphigoid (BP).We examined sera obtained from 21 patients with PV, 39 patients with BP and 22 healthy donors. We performed enzyme-linked immunosorbent assays for soluble BAFF and each disease-specific antibody: antidesmoglein-3 antibody for PV and anti-BP180 antibody for BP.Significant elevations of serum BAFF levels were found in the patients with BP, but not with PV. There was apparently no significant association between the serum BAFF levels and titres of anti-BP180 antibodies in the patients with BP. However, serum BAFF levels tended to be more elevated in patients with a shorter disease duration. There was a tendency that BAFF levels increased before the anti-BP180 antibody levels increased at the onset of BP and quickly decreased in response to treatment.BAFF may be a useful marker for early activation of an autoimmune diathesis and may play a critical role in triggering activation of self-antigen-driven autoreactive B cells in BP.