Meta-analysis of hypertension and osteoporotic fracture risk in women and men
Meta-analysis of hypertension and osteoporotic fracture risk in women and men
复制标题
女性和男性高血压和骨质疏松性骨折风险的荟萃分析
DOI：
10.1007/s00198-017-4050-z
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发表时间：
2017-08-01
影响因子：
4
通讯作者：
Wang, Q.
中科院分区：
文献类型：
--
作者：
Li, C.;Zeng, Y.;Wang, Q.
目前的荟萃分析综合了来自10篇文章的证据，包括28项独立研究，以验证高血压和骨质疏松性骨折风险在女性和男性之间的关联。我们的结果表明，有高血压的个体发生骨质疏松性骨折的风险高于无高血压的个体。然而，报道的结果存在差异。方法系统检索PubMed(1953~2016年10月5日)和Embase(1974年10月5日至2016年10月5日)相关文献。使用随机效应模型得出优势比(OR)和可信区间(CI)。结果我们分析了10篇文章，包括28项独立研究、1,430,431名参与者和148,048例骨质疏松性骨折病例。合并高血压者发生骨质疏松性骨折的风险较非高血压者高(合并OR=1.33，95%可信区间1.25~1.40；I2=0.72.3%，P<0.001)。女性高血压与骨折风险之间的关联(合并OR=1.52，95%可信区间1.30-1.79)略强于男性(合并OR=11.35，95%可信区间1.26-1.44)。在亚洲进行的研究结果与在欧洲进行的研究结果一致。结论高血压与骨质疏松性骨折风险有关。然而，高血压对骨质疏松性骨折影响的生物学机制仍有待阐明。
SummaryThe present meta-analysis synthesized evidence from 10 articles encompassing 28 independent studies to verify the association between hypertension and osteoporotic fracture risk in women and men. Our results indicate that the risk of osteoporotic fracture among individuals with hypertension was higher than that among individuals without hypertension.IntroductionEpidemiological studies have suggested that hypertension is related to osteoporotic fracture. However, discrepancies exist in the reported findings. In this study, a systematic review of relevant published articles was conducted to verify the association between hypertension and osteoporotic fracture risk in women and men.MethodsPubMed (1953_October 5th, 2016) and Embase (1974_October 5th, 2016) were systematically searched for relevant articles. Odds ratios (ORs) and confidence intervals (CIs) were derived using random effect models. Categorical, subgroup, heterogeneity, publication bias, and meta-regression analyses were conducted.ResultsWe analyzed 10 articles encompassing 28 independent studies, 1,430,431 participants, and 148,048 osteoporotic fracture cases. The risk of osteoporotic fracture among individuals with hypertension was higher (pooled OR = 1.33, 95% CI 1.25–1.40;I2= 72.3%,P< 0.001) than that among individuals without hypertension. The association between hypertension and fracture risk was slightly stronger in women (pooled OR = 1.52, 95% CI 1.30–1.79) than in men (pooled OR = 1.35, 95% CI 1.26–1.44). Studies conducted in Asia revealed results that were consistent with those of studies performed in Europe.ConclusionsHypertension is associated with osteoporotic fracture risk. However, the biological mechanisms underlying the effect of hypertension on osteoporotic fracture remain to be elucidated.