The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection.
The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection.
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DOI：
10.1093/nar/gkv1356
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Galperin MY
中科院分区：
文献类型：
--
作者：
Rigden DJ;Fernández-Suárez XM;Galperin MY
2016 年《核酸研究数据库》一期首先概述了三个主要生物信息学中心：美国国家生物技术信息中心 (NCBI)、欧洲生物信息学研究所 (EMBL-EBI) 和瑞士生物信息学研究所 (SIB) 提供的资源。还包括对 62 个新数据库的描述以及对先前在 NAR 中介绍过的 95 个数据库的更新，以及先前在其他地方描述过的 17 个数据库。本期多篇论文涉及核酸资源，包括各种非编码RNA及其相互作用、核酸结构的分子动力学模拟以及两个超级增强子数据库。蛋白质数据库部分包含 EBI 的 Pfam、PDBe 和 PRIDE 数据库的重要更新，以及有关途径、代谢组学和代谢模型的各种资源。本期还包括流行的宏基因组学资源的更新，例如 MG-RAST、EBI 宏基因组学和probeBASE，以及新编译的人类泛微生物社区数据库。新的和更新的数据库中有很大一部分致力于疾病（主要是癌症）的遗传基础以及药物研究的各个方面，包括专利药物的资源、其副作用、撤回的药物和潜在的药物靶标。另外六篇论文介绍了各种抗菌和抗癌肽的最新数据库。整个数据库问题可在核酸研究网站 (http://nar.oxfordjournals.org/) 上免费在线获取。 NAR 在线分子生物学数据库合集 http://www.oxfordjournals.org/nar/database/c/ 已更新，添加了 88 个新资源并删除了 23 个过时的网站，使当前数据库列表达到 1685 个。
The 2016 Database Issue of Nucleic Acids Research starts with overviews of the resources provided by three major bioinformatics centers, the U.S. National Center for Biotechnology Information (NCBI), the European Bioinformatics Institute (EMBL-EBI) and Swiss Institute for Bioinformatics (SIB). Also included are descriptions of 62 new databases and updates on 95 databases that have been previously featured in NAR plus 17 previously described elsewhere. A number of papers in this issue deal with resources on nucleic acids, including various kinds of non-coding RNAs and their interactions, molecular dynamics simulations of nucleic acid structure, and two databases of super-enhancers. The protein database section features important updates on the EBI's Pfam, PDBe and PRIDE databases, as well as a variety of resources on pathways, metabolomics and metabolic modeling. This issue also includes updates on popular metagenomics resources, such as MG-RAST, EBI Metagenomics, and probeBASE, as well as a newly compiled Human Pan-Microbe Communities database. A significant fraction of the new and updated databases are dedicated to the genetic basis of disease, primarily cancer, and various aspects of drug research, including resources for patented drugs, their side effects, withdrawn drugs, and potential drug targets. A further six papers present updated databases of various antimicrobial and anticancer peptides. The entire Database Issue is freely available online on the Nucleic Acids Research website (http://nar.oxfordjournals.org/). The NAR online Molecular Biology Database Collection, http://www.oxfordjournals.org/nar/database/c/, has been updated with the addition of 88 new resources and removal of 23 obsolete websites, which brought the current listing to 1685 databases.