PROGRESSIVE DECLINE IN RENAL-FUNCTION IN DIABETIC-PATIENTS WITH AND WITHOUT ALBUMINURIA
PROGRESSIVE DECLINE IN RENAL-FUNCTION IN DIABETIC-PATIENTS WITH AND WITHOUT ALBUMINURIA
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DOI：
10.2337/diabetes.43.5.649
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发表时间：
1994-05-01
期刊：
影响因子：
7.7
通讯作者：
JERUMS, G
中科院分区：
文献类型：
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作者：
TSALAMANDRIS, C;ALLEN, TJ;JERUMS, G
这项研究描述了从211名糖尿病患者（118名I型，93名II型）中选出的40名患者的亚组中蛋白尿和肾功能的进展模式，随访时间为8-14年。40例患者（18例I型糖尿病，22例II型糖尿病）在研究期间出现白蛋白排泄率（AER）进行性增加和/或肌酐清除率（CC）下降。其中，单独AER升高的患者15例，单独AER升高而CC降低的患者13例，单独CC降低的患者12例，各组I型和II型糖尿病患者的分布相似。在28例蛋白尿增加的患者中，AER以每年30-40%的速度增加，导致AER在研究期间增加4- 8倍，达到20 μ g/min。在25例肾功能下降的患者中，CC以每年4-5 ml/min的速度下降，导致CC大约减半至
This study describes patterns of progression of albuminuria and renal function in a subgroup of 40 patients from a total cohort of 211 diabetic patients (118 type I, 93 type II) followed over a period of 8-14 years. Forty patients (18 with type I diabetes, 22 with type II diabetes) showed progressive increases in albumin excretion rate (AER) and/or decreases in creatinine clearance (CC) during the study period. Of these, AER alone increased in 15 patients, AER increased and CC decreased in 13 patients, and CC alone decreased in 12 patients, with a similar distribution of type I and type II diabetic patients in each group. Of the 28 patients who showed an increase in albuminuria, AER increased at an annual rate of 30-40%, resulting in a 4- to 8-fold increase in AER to >20 mu g/min during the study. Of the 25 patients who showed a decrease in renal function, CC decreased at an annual rate of 4-5 ml/min, resulting in an approximate halving of CC to