The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA): Data on mortality, by HIV status and stage on the HIV care continuum, among the general population in seven longitudinal studies between 1989 and 2014.
The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA): Data on mortality, by HIV status and stage on the HIV care continuum, among the general population in seven longitudinal studies between 1989 and 2014.
复制标题
DOI：
10.12688/gatesopenres.12753.1
复制
发表时间：
2017-11-06
影响因子：
--
通讯作者：
Zaba B
中科院分区：
文献类型：
--
作者：
Slaymaker E;McLean E;Wringe A;Calvert C;Marston M;Reniers G;Kabudula CW;Crampin A;Price A;Michael D;Urassa M;Kwaro D;Sewe M;Eaton JW;Rhead R;Nakiyingi-Miiro J;Lutalo T;Nabukalu D;Herbst K;Hosegood V;Zaba B
艾滋病毒感染者从感染点到诊断到治疗的及时进展对于确保艾滋病毒的有效护理和治疗以及预防与艾滋病毒有关的死亡和感染的传播非常重要。 对于撒哈拉以南非洲的普遍流行病，很难获得可靠的、基于人口的新感染估计数，死亡率数据表明疾病负担，如果沿着从诊断到治疗的连续体分列，常规统计数据和观察性临床研究都无法估计在与护理挂钩之前或脱离护理之后的死亡率。为此，需要基于人口的数据。 非洲人口艾滋病毒/艾滋病纵向数据分析网络汇集了在肯尼亚、马拉维、南非、坦桑尼亚、乌干达和津巴布韦的研究，其中八项研究有必要的数据来估计艾滋病毒状况造成的死亡率，和七个可以估计艾滋病毒护理连续体不同阶段的死亡率。本数据说明描述了一个统一的数据集，其中包含匿名个人-15岁及以上成年人按艾滋病毒状况分列的存活率水平信息。在艾滋病毒感染者中，数据集提供了不同时期的生存信息：感染诊断前;诊断后但与护理联系之前;抗逆转录病毒治疗前护理;抗逆转录病毒治疗开始后的前六个月;连续接受抗逆转录病毒治疗6个月以上的人;以及曾经中断抗逆转录病毒治疗的人。
Timely progression of people living with HIV (PLHIV) from the point of infection through the pathway from diagnosis to treatment is important in ensuring effective care and treatment of HIV and preventing HIV-related deaths and onwards transmission of infection. Reliable, population-based estimates of new infections are difficult to obtain for the generalised epidemics in sub-Saharan Africa. Mortality data indicate disease burden and, if disaggregated along the continuum from diagnosis to treatment, can also reflect the coverage and quality of different HIV services. Neither routine statistics nor observational clinical studies can estimate mortality prior to linkage to care nor following disengagement from care. For this, population-based data are required. The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa brings together studies in Kenya, Malawi, South Africa, Tanzania, Uganda, and Zimbabwe. Eight studies have the necessary data to estimate mortality by HIV status, and seven can estimate mortality at different stages of the HIV care continuum. This data note describes a harmonised dataset containing anonymised individual-level information on survival by HIV status for adults aged 15 and above. Among PLHIV, the dataset provides information on survival during different periods: prior to diagnosis of infection; following diagnosis but before linkage to care; in pre-antiretroviral treatment (ART) care; in the first six months after ART initiation; among people continuously on ART for 6+ months; and among people who have ever interrupted ART.